Results 61 to 70 of about 89,870 (258)

Epizootic Activity of Natural Plague Foci of the Russian Federation in 2008–2017 and Forecast for 2018

Проблемы особо опасных инфекций, 2018
Objective of the study was to assess the condition of parasitic systems and activity of natural plague foci of the Russian Federation in 2008–2017. Epizooties of varying intensity were registered in East-Caucasian high-mountain, Gorno-Altai high-mountain,
N. V. Popov, A. A. Kuznetsov, A. N. Matrosov, V. M. Korzun, D. B. Verzhutsky, S. A. Vershinin, S. A. Kosilko, T. M. Innokent’eva, M. P. Grigor’ev, D. Yu. Degtyarev, E. V. Gerasimenko, V. M. Dubyansky, M. M. Shilov, V. P. Toporkov, E. S. Zenkevich, V. P. Popov, A. A. Lopatin, V. E. Bezsmertny, S. V. Balakhonov, A. N. Kulichenko, V. V. Kutyrev   +20 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

THE ANALYSIS OF DIGITAL MODEL OF SOIL AND GEOGRAPHICAL CONDITIONS OF SMOLENSK REGION AT THE STUDYING OF NATURAL FOCI INFECTIONS (ON TULYAREMIYA'S EXAMPLE)

InterCarto. InterGIS, 2013
This work describes using of soil’s digital model at the studying of natural foci infections. Distribution of natural foci infections depends on a complex of factors, including soil’s conditions.
T. V. Vatlina, S. Evdokimov
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

The Small Molecule Inhibitor of the Type III Secretion System Fluorothiazinone Affects Flagellum Surface Presentation and Restricts Motility in Gram-Negative Bacteria

Antibiotics
Background/Objectives: Fluorothiazinone (FT), a small molecule of the 2,4-disubstituted-4H-[1,3,4]-thiadiazine-5-one class, is known to inhibit the type III secretion system (T3SS) in Gram-negative bacteria and has shown therapeutic potential in animal ...
Alexey Slonov, Mariam Abdulkadieva, Egor Kalinin, Natalya Bondareva, Lydia Kapotina, Svetlana Andreevskaya, Natalia Shevlyagina, Anna Sheremet, Elena Sysolyatina, Vladimir Zhukhovitsky, Mikhail Vasiliev, Oleg Petrov, Svetlana Ermolaeva, Nailya Zigangirova, Alexander Gintsburg   +14 more
doaj   +1 more source

Ecology of brucellosis of the European hare in the Czech Republic

Veterinární Medicína, 2005
A geographic information system was used for the analysis of ecological conditions of distribution of natural foci of brucellosis in the European hare (Lepus europaeus) and their long-term persistence in the Czech Republic.
J. Pikula, M. Beklova, Z. Holesovska, B. Skocovska, F. Treml   +4 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Two Novel Yersinia pestis Bacteriophages with a Broad Host Range: Potential as Biocontrol Agents in Plague Natural Foci. [PDF]

Viruses, 2022
Jin H, Zhong Y, Wang Y, Zhang C, Guo J, Shen X, Li C, Huang Y, Xiong H, Wang P, Li W.   +10 more
europepmc   +1 more source