Results 81 to 90 of about 89,262 (295)

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Targeting the DNA double strand break repair machinery in prostate cancer [PDF]

, 2011
Regardless of the achievable remissions with first line hormone therapy in patients with prostate cancer (CaP), the disease escapes the hormone dependent stage to a more aggressive status where chemotherapy is the only effective treatment and no ...
Fadhel S. Shaheen, Pawel Znojek, Fisher Ann, Robson Craig N., Graeme C M Smith, Leung, H.Y., Nicola J Curtin, Craig N. Robson, Martin Webster, Znojek Pawel, Plummer Ruth, Curtin Nicola J., Gaughan, L., Curtin, N.J., Smith, G.C. M., Ruth Plummer, Fadhel S Shaheen, Craig N Robson, Shaheen Fadhel S., Smith Graeme C. M., Nicola J. Curtin, Robson, C.N., Plummer, R., Ann Fisher, Gaughan Luke, Webster, M., Znojek, P., Hing Y. Leung, Shaheen, F.S., Fisher, A., Hing Y Leung, Webster Martin, Luke Gaughan, Leung Hing Y., Graeme C. M. Smith   +34 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Two Novel Yersinia pestis Bacteriophages with a Broad Host Range: Potential as Biocontrol Agents in Plague Natural Foci. [PDF]

Viruses, 2022
Jin H, Zhong Y, Wang Y, Zhang C, Guo J, Shen X, Li C, Huang Y, Xiong H, Wang P, Li W.   +10 more
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

[Natural foci of ornithosis in Kazakhstan].

Zhurnal mikrobiologii, epidemiologii i immunobiologii, 1976
An investigation (clinical, immunological and epidemiological) of the workers of various fowl-farms was carried out in various regions of Kazakhstan for a number for years; the sera of domestic fowl and birds was studied as well. On the basis of examination of 6264 persons the greatest percentage of ornithosis was revealed among the workers of the ...
N S, Evdokimova, Iu A, Il'inskii, A D, Tkachenko   +2 more
openaire   +1 more source

Analysis of the Current Epidemiological Situation in Natural Plague Foci around the World. Enhancement of the Effectiveness of Epidemiological Surveillance in Natural Plague Foci of the Russian Federation and Forecast of their Epizootic Activity for 2019

, 2019
The paper presents the analysis of epidemic activity of natural plague foci around the world, including in CIS and the Russian Federation, over the period of 2000–2018.
G. A. Eroshenko, E. V. Kouklev, A. N. Matrosov, N. D. Pakskina, E. S. Zenkevich, V. V. Kutyrev, I. G. Karnaukhov, S. V. Balakhonov, V. M. Korzun, T. Z. Ayazbaev, A. A. Kuznetsov, N. V. Popov, V. P. Popov, A. V. Ivanova, A. M. Porshakov, A. A. Lopatin, S. A. Kosilko   +16 more
core   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

MODIFICATIONS TO THE BOUNDARIES OF THE NATURAL PLAGUE FOCI IN THE VOLGA-URAL INTERFLUVE

, 2017
Objective of the study is to locate the present-day sites and sizes of the natural plague foci in the Volga-Ural Interfluve. Materials and methods. According to the results of the field and office mapping, 2015 in the Volga-Ural steppe and sandy plague ...
A. A. Kuznetsov, A. N. Matrosov, V. N. Chekashov, M. M. Shilov, A. M. Porshakov   +4 more
core   +1 more source