Results 71 to 80 of about 89,870 (258)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

The Experience of Determining the Natural Boundary between the Precaspian Sandy and Dagestan Plain-Piedmont Natural Plague Foci Using Artificial Intelligence Elements

Проблемы особо опасных инфекций
The aim of the study was to determine the natural boundary of the focal territory, in particular, the boundary between the Precaspian sandy and Dagestan plain-piedmont natural foci of plague.
V. M. Dubyansky, U. M. Ashibokov, A. Kh. Khalidov, A. A. Kas’yan   +3 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Epizootic Activity of Natural Plague Foci in the Russian Federation in 2013 and Prognosis for the Year of 2014

Проблемы особо опасных инфекций, 2014
Analyzed are the data of the epizootiologic survey of plague enzootic territories in Russia in 2013. Evaluated are the numbers of major carriers and vectors as well as the epizootic activity of natural foci of different types.
N. V. Popov, V. E. Bezsmertny, V. P. Toporkov, A. N. Matrosov, T. V. Knyazeva, A. A. Kuznetsov, V. P. Popov, D. B. Verzhutsky, V. M. Korzun, E. V. Chipanin, V. M. Dubyansky, O. V. Maletskaya, M. P. Grigoryev, S. V. Balakhonov, A. N. Kulichenko, V. V. Kutyrev   +15 more
doaj   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Impact of the dog population and household environment for the maintenance of natural foci of Leishmania infantum transmission to human and animal hosts in endemic areas for visceral leishmaniasis in Sao Paulo state, Brazil. [PDF]

PLoS One, 2021
Matsumoto PSS, Hiramoto RM, Pereira VBR, Camprigher VM, Taniguchi HH, de Raeffray Barbosa JE, Cortez LRPB, Fonseca EDS, Guimarães RB, Tolezano JE.   +9 more
europepmc   +1 more source

[Natural foci of ornithosis in Kazakhstan].

Zhurnal mikrobiologii, epidemiologii i immunobiologii, 1976
An investigation (clinical, immunological and epidemiological) of the workers of various fowl-farms was carried out in various regions of Kazakhstan for a number for years; the sera of domestic fowl and birds was studied as well. On the basis of examination of 6264 persons the greatest percentage of ornithosis was revealed among the workers of the ...
N S, Evdokimova, Iu A, Il'inskii, A D, Tkachenko   +2 more
openaire   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

[Tularemia in inactive natural foci].

Zhurnal mikrobiologii, epidemiologii i immunobiologii, 2003
The data on the epidemiological and epizootological manifestations of tularemia on the territory of the Ulyanovsk region are presented. The characteristics describing the process of the of Francisella tularensis circulation as well as the environmental objects, most important for the manifestations of tularemia infection, are given.
A A, Nafeev, A S, Korobeĭnikova, Z V, Briginevich, E I, Sibaeva, N M, Nikishina   +4 more
openaire   +1 more source