Results 81 to 90 of about 5,007,046 (300)

Non-realizability of the Torelli group as area-preserving homeomorphisms [PDF]

, 2019
Nielsen realization problem for the mapping class group $\text{Mod}(S_g)$ asks whether the natural projection $p_g: \text{Homeo}_+(S_g)\to \text{Mod}(S_g)$ has a section.
Chen, Lei, Markovic, Vladimir
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Controlling Linguistic Style Aspects in Neural Language Generation

, 2017
Most work on neural natural language generation (NNLG) focus on controlling the content of the generated text. We experiment with controlling several stylistic aspects of the generated text, in addition to its content.
Ficler, Jessica, Goldberg, Yoav
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

The Classical approach to distribution and the “natural system” [PDF]

The modern reformulation of Classical analysis of value and distribution built upon Sraffa’s Production of Commodities provides quite a general and open framework to study distributive relationships, that deserves to be still explored.
Bellino, Enrico
core   +1 more source

Symmetries and observables in topological gravity

, 2004
After a brief review of topological gravity, we present a superspace approach to this theory. This formulation allows us to recover in a natural manner various known results and to gain some insight into the precise relationship between different ...
Abe M, Aldo Deandrea, Baulieu L, Baulieu L, Baulieu L, Becchi C M, Becchi C M Imbimbo C, Bertlmann R A, Boldo J L, Chandía O, Chandía O, Clisthenis P Constantinidis, Constantinidis C P, Constantinidis C P, de Medeiros P, Eguchi T, François Gieres, Gieres F, Guo H Y, Kanno H, Kanno H, Lee H Y, Mardones A, Matthieu Lefrançois, Menaa M, Myers R, Nakamichi A, Nieh H T, Oda I, Oda I, Olivier Piguet, Perez A, Piguet O, Smolin L Starodubtsev A, Stora R Thuillier F Wallet J C R Coquereaux M Dubois-Violette P Flad, Tahiri M, Thiemann T, Witten E, Witten E, Witten E, Yu F   +40 more
core   +3 more sources

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Adoption of CRISPR-Cas for crop production: present status and future prospects [PDF]

PeerJ
Background Global food systems in recent years have been impacted by some harsh environmental challenges and excessive anthropogenic activities. The increasing levels of both biotic and abiotic stressors have led to a decline in food production, safety ...
Akinlolu Olalekan Akanmu, Michael Dare Asemoloye, Mario Andrea Marchisio, Olubukola Oluranti Babalola   +3 more
doaj   +2 more sources

How a Christian Ethic of Care Can Inform the Organization and Structure of Schools of Education

, 2012
A natural outcome of a Christian ethic of care is the adoption of structures and organizations that facilitate or enhance this kind of caring. This article investigates these kinds of structures as they relate to schools of education.
Shotsberger, Paul
core