Results 41 to 50 of about 5,367,272 (280)
Balanced Definition of Thresholds for Mode Tracking in a Long-Term Seismic Monitoring System
Geosciences, 2023 The catastrophic events of recent years have strengthened the awareness of the fragility of the built heritage and the importance of careful and targeted maintenance.
Stefania Coccimiglio +4 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
DIAGNOSIS OF DAMAGES OF PLANE WINGS ATTACHMENT POINTS USING VIBRATION’S PARAMETERS
Приборы и методы измерений, 2015 A method of diagnostics of power structures based on shock excitation of eiqenmodes and used as a diagnostic parameter of modal characteristics (natural frequencies and mode shapes) is proposed.
A. V. Kositsyn, A. A. Sheynikov
doaj
Sensors, 2023 This paper presents the results of experimental and numerical studies of the dynamic parameters of composite cylindrical shells loaded under axial tension. Five composite structures were manufactured and loaded up to 4817 N.
Aleksey Mironov +3 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Dynamic Modeling and Analysis of a Driving Passenger Vehicle
Applied Sciences, 2023 This study presents a dynamic model of a passenger vehicle and analyzes its dynamic characteristics and responses. A dynamic vehicle model with seven degrees of freedom was established to analyze the behavior of a driving vehicle.
Seen Yun +5 more
doaj +1 more source
Frequency distributions and natural laws in geochemistry [PDF]
Geological Society, London, Special Publications, 2006 Abstract The chemical composition of natural waters is derived from many different sources of solutes, including gases and aerosols from the atmosphere, weathering and erosion of rocks and soil, solution or precipitation reactions occurring below the land surface, and effects resulting from human activities.
BUCCIANTI, ANTONELLA +2 more
openaire +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source