Results 71 to 80 of about 110,765 (287)

NNMT Orchestrates Metabolic‐Epigenetic Reprogramming to Drive Macrophage‐Myofibroblast Transition in Hypertrophic Scarring

Advanced Science, EarlyView.
In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine‌ (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong, Weinan Guo, Yuxuan Qian, Wenyan Jin, Xiaozhen Li, Jingyuan Yang, Qingrong Ni, Shuang Wu, Fanni Li, Hua Wang, Chunying Li, Hong Cai   +11 more
wiley   +1 more source

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

Swelling behavior and mechanism of perfluoro rubber in methanol environments

You-qi chuyun
ObjectiveWith the advancement of the “dual carbon” strategy, the demand for pipeline transportation of methanol as an alternative fuel is gradually increasing.
Xinsheng WANG, Xu HU, Xianghe WEI, Song LIU, Haiyang WU, Xueling WU, Kexi LIAO, Shujuan QIU   +7 more
doaj   +1 more source

Liquified Natural Gas Send-Out Scenario in Gas Transmission Pipeline Network

IOP Conference Series: Earth and Environmental Science
Abstract The depletion of gas reserves from conventional wells is the cause of the decrease in supply. If these problems are not overcome, there will be a pressure drop that causes damage to the transmission pipeline network. Therefore, adding LNG is needed by increasing the supply (send out), which must meet the West Java Area peak load
Ibnu Lukman Pratama, Arida Nesa Aryandini, Nguyen Thi Phuong   +2 more
openaire   +1 more source

Online simulation of natural gas pipeline networks: theories and practices

You-qi chuyun, 2022
To deal with the challenges brought by the large scaling and complication of natural gas pipeline networks, promote the safe operation, and improve the quality and efficiency through fully using the data achievements obtained in pipeline automation and digitalization, online simulation is becoming an urgent and important means for the scheduling ...
Shouxi WANG, Chuanzhong DENG, Chuansheng CHEN, Wei LI, Jun LI, Xiang GAO   +5 more
openaire   +1 more source

A quantitative risk analysis method for the natural gas pipeline network [PDF]

WIT Transactions on Information and Communication Technologies, 2010
Natural gas as a fuel is supplied in the most populous urban areas with the risk threatening public safety managed properly. Regulatory authorities in many countries are moving away from prescriptive approaches for keeping natural gas pipelines safe.
Y.-D. Jo, K.-S. Park, H.-S. Kim, J.-J. Kim, J.-Y. Kim, J.-W. Ko   +5 more
openaire   +1 more source

A Review on Biodegradable Materials of Sustainable Soft Robotics and Electronics

Advanced Science, EarlyView.
Biodegradable materials are gaining increasing attention in soft robotics and electronics due to their environmental friendliness, showing great potential for sustainability. In this review, the classification of biodegradable materials, their applications in the field of soft robotics and electronics, as well as the challenges and future prospects ...
Yizhu Xie, Jiaxin Han, Xingyi Dai, Xuyang Zhang, Kangwen Xiao, Junhui Huang, Yajun Cao, Aihua Zhong, Long‐Biao Huang   +8 more
wiley   +1 more source

The Evolutionarily Conserved TPM1 Super‐Enhancer Drives Skeletal Muscle Regeneration via Mechanotransduction Signaling

Advanced Science, EarlyView.
By integrating biomechanical and epigenetic cues, the evolutionarily conserved TPM1 super‐enhancer drives myogenesis via TEAD4‐mediated chromatin looping. This mechanism produces species‐specific outputs (linear TPM1 mRNA in mice and CircTPM1 in bovine) that activate PI3K/AKT mechanotransduction and the MYH10/MYL3 axis to execute cytoskeletal ...
Ruimen Zhang, Wanyou Feng, Yanyan Yang, Yu Pan, Chaoxia Zou, Leyi Wang, Sanbao Zhang, Yimin Zhao, Yongmei Wu, Jinling Wang, Jianwei Zou, Kehe Cen, Yongwang Zhang, Han Huang, Yurong Xu, Li Zhong, Hailong Gong, Juanru Cheng, Jingyuan Liang, Zihua Zheng, Qinyang Jiang, Jingwei Wei, Hui Li, Minhui Liang, Deshun Shi, Sufang Yang, Yanfei Deng, Yingming Wei   +27 more
wiley   +1 more source

Feasibility of Carbon Dioxide as Cushion Gas in Depleted Gas Reservoirs: An Experiment Study on CO₂–CH₄ Dispersion during Flow Alternation

Energies
This study investigates the feasibility of utilizing carbon dioxide (CO2) as a cushion gas in depleted reservoirs for enhanced gas storage efficiency and carbon sequestration against the backdrop of rising natural gas stable supply demand and climate ...
Jinhui Yang, Binshan Ju, An Yang, Zixian Cui, Meng Wang, Yapeng Tian, Hengchen Qi   +6 more
doaj   +1 more source

Recent Advances in Decoupling Strategies for Soft Sensors

Advanced Science, EarlyView.
This review provides an overview of recent advances in decoupling strategies for soft sensors. It summarizes single‐modal sensors that are insensitive to stretching, bending, crosstalk, and other environmental interferences, and highlights emerging multimodal decoupling methods enabled by spatiotemporal information and machine learning.
Yangbo Yuan, Wanqing Zhang, Jia‐Yu Yang, Manqi Peng, Huanyu Cheng   +4 more
wiley   +1 more source