Results 71 to 80 of about 54,973 (267)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
International Journal of the Commons, 2013 Plant genetic resources for food and agriculture (PGRFA) were once widely considered to be global public goods. Recently, however, access to subsets of PGRFA has been subject to various forms of exclusive technological and legal restrictions. In reaction,
Michael Halewood
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Rawls´ legacy: a limited possibility of a non-speciesist environmental justice
Ethic@: an International Journal for Moral Philosophy, 2005 Publishing A Theory of Justice in 1971 John Rawls defined a conceptual realm of justice as that of a well-ordered society in which some principles of justice should be tested before seeking to apply them to distribute primary goods among co-operative ...
Sônia T. Felipe
doaj
Ingeniería Investigación y Desarrollo, 2013 This paper addresses the theoretical and conceptual bases related to economic valuation of environmental goods and services for designing of a methodological model, as well as approaches for categorization, identification and classification of such goods
Claudia Marcela Camargo-López +3 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
THE IMPORTANCE OF GOODS PRODUCTION AND INTERMEDIATE CONSUMPTION FOR AN INCREASED GDP [PDF]
Challenges of the Knowledge Society, 2011 Human existence is conditioned, of course, by the consumption of goods to meet the needs. Using the property to obtain other goods in this way is not consumption, but production.
RADU-MARCEL JOIA
doaj
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Cost and operational parameters of choosing cargo vehicles
Вестник СибАДИ, 2017 The authors consider the problem of choosing a rolling stock on the basis of cost and natural parameters at delivering goods by automobile transport.
O. V. Bykovа, D. I. Zarudnev
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source