Results 101 to 110 of about 1,580,667 (265)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Growth performance, intestinal histomorphology, gut microflora and ghrelin gene expression analysis of broiler by supplementing natural growth promoters: A nutrigenomics approach. [PDF]

Saudi J Biol Sci, 2021
Gilani SMH, Rashid Z, Galani S, Ilyas S, Sahar S, Zahoor-Ul-Hassan, Al-Ghanim K, Zehra S, Azhar A, Al-Misned F, Ahmed Z, Al-Mulham N, Mahboob S.   +12 more
europepmc   +1 more source

Characterising the metabolic rewiring of extremely slow growing Komagataella phaffii

Microbial Biotechnology
Retentostat cultivations have enabled investigations into substrate‐limited near‐zero growth for a number of microbes. Quantitative physiology at these near‐zero growth conditions has been widely discussed, yet characterisation of the fluxome is ...
Benjamin Luke Coltman, Corinna Rebnegger, Brigitte Gasser, Jürgen Zanghellini   +3 more
doaj   +1 more source

Improved Mechanistic Degradation Modes Modeling of Lithium and Sodium Plating

Batteries
Lithium and sodium plating are inevitable when using negative electrodes with an electrochemical potential close to one of the charge carriers. Typical testing and modeling assume that plating occurs at 0 V when measured against the charge carrier. While
David Beck, Agata Greszta, Alexander Roberts, Matthieu Dubarry   +3 more
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Protein production dynamics and physiological adaptation of recombinant Komagataella phaffii at near-zero growth rates

Microbial Cell Factories
Background Specific productivity (qP) in yeast correlates with growth, typically peaking at intermediate or maximum specific growth rates (μ). Understanding the factors limiting productivity at extremely low μ might reveal decoupling strategies, but ...
Corinna Rebnegger, Benjamin L. Coltman, Viktoria Kowarz, David A. Peña, Axel Mentler, Christina Troyer, Stephan Hann, Harald Schöny, Gunda Koellensperger, Diethard Mattanovich, Brigitte Gasser   +10 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source

Evaluating the natural growth rate of metastatic cancer to the brain. [PDF]

Surg Neurol Int, 2020
Kobets AJ, Backus R, Fluss R, Lee A, Lasala PA.   +4 more
europepmc   +1 more source