Results 51 to 60 of about 1,640,247 (265)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

THE NORTHERN TERRITORIES OF WESTERN SIBERIA: DEMOGRAPHIC TRENDS AND GROWTH PARADOXES

Север и рынок: формирование экономического порядка
This paper analyzes socio-demographic trends over the past sixty years in the northern territories of Western Siberia, specifically the Khanty-Mansiysk and Yamalo-Nenets Autonomous Okrugs. The study spans from the initial development of mineral resources
Andrei G. Shelomentsev, Vladimir M. Kurikov, Kseniya S. Goncharova, Alina V. Istratii   +3 more
doaj   +1 more source

Pesticidal Activity of Sundarban Mangrove Plant Extracts against Sitophilus Pests and Identification of Active Constituents Using LC-MS

Advances in Pharmacological and Pharmaceutical Sciences, 2021
Plants act as a rich source of novel natural pesticides. In the backdrop of the recent revival of interest in developing plant-based insecticides, this study was carried out to investigate the pesticidal activity of Sundarban mangrove plants.
Md. Abdur Rahman, Rinku Rani Paul, Chaina Biswas, Hakima Akter, Razina Rouf, Sushmita Nath, Jamil A. Shilpi, Lutfun Nahar, Stayajit D. Sarker, Shaikh Jamal Uddin   +9 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Molecular docking study of sea urchin (Arbacia lixula) peptides as multi-target inhibitor for non-small cell lung cancer (NSCLC) associated proteins. [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2021
Context: Lung cancer is a type of cancer that causes the most deaths worldwide. The most common type of lung cancer is non-small cell lung cancer (NSCLC). Sea urchin (Arbacia lixula) has high potential as an anti-NSCLC agent.
Muhammad Hermawan Widyananda, Setyaki Kevin Pratama, Rizky Senna Samoedra, Fikriya Novita Sari, Viol Dhea Kharisma, Arif Nur Muhammad Ansori, Yulanda Antonius   +6 more
doaj  

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Holder continuity of bounded generalized solutions for nonlinear fourth-order elliptic equations with strengthened coercivity and natural growth terms

Electronic Journal of Differential Equations, 2017
In this article we extend the author's previous results on the existence of bounded generalized solutions of a Dirichlet problem for nonlinear elliptic fourth-order equations with the principal part satisfying a strengthened coercivity condition, and ...
Mykhailo V. Voitovych
doaj  

Demographic Elements [PDF]

Revista Română de Sociologie, 2010
The author sets out to present the evolution of the population in Osica de Sus commune in the period between 1871 and 2009, with a focus on the evolution of the main demographic processes which occurred and continue to occur in the contemporary period.
ION PAUL POPESCU
doaj  

Demographic potential of sex-age structure as a factor of population dynamics

Статистика и экономика, 2019
The study aims to assess the sex-age population structure in terms of its impact on the up-coming dynamics of natural increase and, consequently, on the general change in the population size.
Vladimir N. Arkhangelskiy, Yuliya V. Zinkina, Sergey G. Shulgin   +2 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source