Results 61 to 70 of about 5,287,723 (308)

THE NORTHERN TERRITORIES OF WESTERN SIBERIA: DEMOGRAPHIC TRENDS AND GROWTH PARADOXES

open access: yesСевер и рынок: формирование экономического порядка
This paper analyzes socio-demographic trends over the past sixty years in the northern territories of Western Siberia, specifically the Khanty-Mansiysk and Yamalo-Nenets Autonomous Okrugs. The study spans from the initial development of mineral resources
Andrei G. Shelomentsev   +3 more
doaj   +1 more source

Components of regional population growth, 1986-2001 [PDF]

open access: yes, 2004
The vitality of a region is frequently assessed by looking at its population growth pattern. This is seen as being linked to its economic and social vibrancy.
Baxendine, Sandra   +2 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Molecular docking study of sea urchin (Arbacia lixula) peptides as multi-target inhibitor for non-small cell lung cancer (NSCLC) associated proteins. [PDF]

open access: yesJournal of Pharmacy & Pharmacognosy Research, 2021
Context: Lung cancer is a type of cancer that causes the most deaths worldwide. The most common type of lung cancer is non-small cell lung cancer (NSCLC). Sea urchin (Arbacia lixula) has high potential as an anti-NSCLC agent.
Muhammad Hermawan Widyananda   +6 more
doaj  

Natural resources and regional growth [PDF]

open access: yes
Regional economics ; Natural ...
Ronald H. Schmidt
core  

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

Demographic potential of sex-age structure as a factor of population dynamics

open access: yesСтатистика и экономика, 2019
The study aims to assess the sex-age population structure in terms of its impact on the up-coming dynamics of natural increase and, consequently, on the general change in the population size.
Vladimir N. Arkhangelskiy   +2 more
doaj   +1 more source

Safe growth and natural disaster [PDF]

open access: yes
Smart growth planning is beginning to include safe growth techniques, which can minimize the effects of natural disasters.Natural ...
Kristina Egan
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Holder continuity of bounded generalized solutions for nonlinear fourth-order elliptic equations with strengthened coercivity and natural growth terms

open access: yesElectronic Journal of Differential Equations, 2017
In this article we extend the author's previous results on the existence of bounded generalized solutions of a Dirichlet problem for nonlinear elliptic fourth-order equations with the principal part satisfying a strengthened coercivity condition, and ...
Mykhailo V. Voitovych
doaj  

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