Results 41 to 50 of about 5,838 (169)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Hydrogen embrittlement behavior of typical hydrogen-blended natural gas pipeline steel

You-qi chuyun, 2022
Currently, it is most economical to transport hydrogen with the existing natural gas pipelines by blending it into the natural gas among the storage and transportation technologies of hydrogen energy, and thus the transportation technology of hydrogen ...
Yu-xing LI, Rui ZHANG, Cui-wei LIU, Cai-lin WANG, Hong-chao YANG, Qi-hui HU, Jia-xuan ZHANG, Xiu-sai XU, Hui-min ZHANG   +8 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Natural Hydrogen in Uruguay: Catalog of H₂-Generating Rocks, Prospective Exploration Areas, and Potential Systems

Geosciences
The increasing demand for carbon-free energy in recent years has positioned hydrogen as a viable option. However, its current production remains largely dependent on carbon-emitting sources. In this context, natural hydrogen, generated through geological
Marcos Sequeira, Ethel Morales, Isabelle Moretti, Gerardo Veroslavsky, Facundo Plenc, Roberto d’Avila, Hector de Santa Ana   +6 more
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Characterizing Natural Hydrogen Occurrences in the Paris Basin From Historical Drilling Records

Geochemistry, Geophysics, Geosystems
This study investigates natural hydrogen (H2) occurrences in the Paris Basin, using Optical Character Recognition (OCR) technology to analyze an extensive, yet underexploited, database that contains historic drilling records.
Nicolas Lefeuvre, Eric Thomas, Laurent Truche, Frédéric‐Victor Donzé, Thibault Cros, Johann Dupuy, Laura Pinzon‐Rincon, Christophe Rigollet   +7 more
doaj   +1 more source

Natural hydrogen system evaluation in the São Francisco Basin (Brazil)

Science and Technology for Energy Transition
The São Francisco Basin (SFB), a double foreland bordered by two Neoproterozoic belts, hosts a proven hydrogen (H2) system, demonstrated by high concentrations in boreholes and numerous surface H2 emissions, some long-term monitored. However, no detailed
de Freitas Vivian Azor, Prinzhofer Alain, Françolin João Batista, Ferreira Francisco José Fonseca, Moretti Isabelle   +4 more
doaj   +1 more source

Research status and evolution trend of pipeline transportation of hydrogen-blended natural gas based on knowledge graph

You-qi chuyun, 2022
Pipeline transportation of hydrogen-blended natural gas is an effective means to solve the problems of economical, large-scale, long-distance and cross-regional transportation of hydrogen in the process of its utilization.Herein, the analysis of ...
WU Qibing, ZHANG Hang, ZHANG Meng, ZHANG Xiaoying, DONG Shaohua   +4 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source