Results 61 to 70 of about 1,158,756 (302)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Natural Hydrogen in Uruguay: Catalog of H₂-Generating Rocks, Prospective Exploration Areas, and Potential Systems

Geosciences
The increasing demand for carbon-free energy in recent years has positioned hydrogen as a viable option. However, its current production remains largely dependent on carbon-emitting sources. In this context, natural hydrogen, generated through geological
Marcos Sequeira, Ethel Morales, Isabelle Moretti, Gerardo Veroslavsky, Facundo Plenc, Roberto d’Avila, Hector de Santa Ana   +6 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Natural hydrogen system evaluation in the São Francisco Basin (Brazil)

Science and Technology for Energy Transition
The São Francisco Basin (SFB), a double foreland bordered by two Neoproterozoic belts, hosts a proven hydrogen (H2) system, demonstrated by high concentrations in boreholes and numerous surface H2 emissions, some long-term monitored. However, no detailed
de Freitas Vivian Azor, Prinzhofer Alain, Françolin João Batista, Ferreira Francisco José Fonseca, Moretti Isabelle   +4 more
doaj   +1 more source

Research status and evolution trend of pipeline transportation of hydrogen-blended natural gas based on knowledge graph

You-qi chuyun, 2022
Pipeline transportation of hydrogen-blended natural gas is an effective means to solve the problems of economical, large-scale, long-distance and cross-regional transportation of hydrogen in the process of its utilization.Herein, the analysis of ...
WU Qibing, ZHANG Hang, ZHANG Meng, ZHANG Xiaoying, DONG Shaohua   +4 more
doaj   +1 more source

Natural hydrogen development-potential and challenges

International Journal of Hydrogen Energy
Natural hydrogen has recently been identified as a potential source for future energy systems. This paper investigates the technical development potential of natural hydrogen by estimating, for some recent finds and identified prospects, in-place and recoverable hydrogen, well productivity, water production and other byproducts that a future ...
Arnout JW. Everts, Jos Bonnie, Ramon Loosveld   +2 more
openaire   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Characterizing Natural Hydrogen Occurrences in the Paris Basin From Historical Drilling Records

Geochemistry, Geophysics, Geosystems
This study investigates natural hydrogen (H2) occurrences in the Paris Basin, using Optical Character Recognition (OCR) technology to analyze an extensive, yet underexploited, database that contains historic drilling records.
Nicolas Lefeuvre, Eric Thomas, Laurent Truche, Frédéric‐Victor Donzé, Thibault Cros, Johann Dupuy, Laura Pinzon‐Rincon, Christophe Rigollet   +7 more
doaj   +1 more source

Sensing Hydrogen Seeps in the Subsurface for Natural Hydrogen Exploration

Applied Sciences, 2022
The recent detection of natural hydrogen seeps in sedimentary basin settings has triggered significant interest in the exploration of this promising resource. If large economical resources exist and can be extracted from the sub-surface, this would provide an opportunity for natural hydrogen to contribute to the non-carbon-based energy mix.
Mederic Mainson, Charles Heath, Bobby Pejcic, Emanuelle Frery   +3 more
openaire   +2 more sources

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source