Results 121 to 130 of about 749,043 (396)

FEM1B enhances TRAIL‐induced apoptosis in T lymphocytes and monocytes

FEBS Open Bio, EarlyView.
FEM1B facilitates TRAIL‐induced apoptosis through distinct mechanisms in T lymphocytes and monocytes. In T lymphocytes, FEM1B engages with TRAF2, leading to a reduction in TRAF2 expression, which subsequently lessens TRAF2's inhibitory influence on caspase‐8.
Chenbo Yang, Wenhui Yu, Cui Dang, Jingjing Zhang, Jiahan Lu, Jing Xue   +5 more
wiley   +1 more source

MHC class I chain-related protein A shedding in chronic HIV-1 infection is associated with profound NK cell dysfunction [PDF]

, 2010
Natural killer (NK) cells play a critical role in host defense against viral infections. However chronic HIV-1 infection is associated with an accumulation of dysfunctional NK cells, that poorly control viral replication.
Alter, Anne Nolting, Anne-Sophie Dugast, Arase, Bauer, Biron, Brown, Cao, Cerboni, Dezube, Diefenbach, Ellen Nagami, Etzioni, Fang, Fdez-Morera, Galit Alter, Gambelunghe, Gerd Faetkenheuer, Groh, Groh, Groh, Hijova, Huard, Ildiko Toth, Jinushi, Kaiser, Katherine Kane, Kiessling, Lanier, Lanier, Li, Limou, Linsley, Liu, Lopez-Arbesu, Lozzio, Marcus Altfeld, Mary F. Carrington, Mavilio, Mavilio, Pia Hartmann, Ramankulov, Raulet, Rutger Luteijn, Salih, Salih, Shimizu, Shirts, Smyth, Stephanie Jost, Suzannah Rihn, Trinchieri, Valitutti, Vetter, Waldhauer, Webster, Wiemann, Yokoyama, Zaunders   +58 more
core   +1 more source

A pan-cancer single-cell panorama of human natural killer cells

Cell, 2023
Fei Tang, Jinhu Li, L. Qi, Dongfang Liu, Yufei Bo, Shishang Qin, Yuhui Miao, Kezhuo Yu, Wenhong Hou, Jianan Li, Jirun Peng, Z. Tian, Linnan Zhu, Hui Peng, Dongfang Wang, Zemin Zhang   +15 more
semanticscholar   +1 more source

Natural Killer Cells for Immunotherapy – Advantages of the NK-92 Cell Line over Blood NK Cells

Frontiers in Immunology, 2016
Natural killer (NK) cells are potent cytotoxic effector cells for cancer therapy and potentially for severe viral infections. However, there are technical challenges to obtain sufficient numbers of functionally active NK cells from a patient’s blood ...
H. Klingemann, L. Boissel, F. Toneguzzo
semanticscholar   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Natural Killer (NK) Cell Education Differentially Influences HIV Antibody-Dependent NK Cell Activation and Antibody-Dependent Cellular Cytotoxicity

Frontiers in Immunology, 2017
Immunotherapy using broadly neutralizing antibodies (bNAbs) endowed with Fc-mediated effector functions has been shown to be critical for protecting or controlling viral replication in animal models.
Nicole F. Bernard, Nicole F. Bernard, Nicole F. Bernard, Nicole F. Bernard, Zahra Kiani, Zahra Kiani, Alexandra Tremblay-McLean, Alexandra Tremblay-McLean, Sanket A. Kant, Sanket A. Kant, Christopher E. Leeks, Christopher E. Leeks, Franck P. Dupuy   +12 more
doaj   +1 more source

Impaired natural killer cell phenotype and function in idiopathic and heritable pulmonary arterial hypertension [PDF]

, 2012
BACKGROUND: Beyond their role as innate immune effectors, natural killer (NK) cells are emerging as important regulators of angiogenesis and vascular remodeling.
Campbell, Kate, Chang, Chiwen, Colucci, Francesco, Exley, Andrew, Jones, Des, Long, Lu L., Machado, Rajiv, Morrell, Nicholas W., Ormiston, Mark L., Pepke-Zaba, Joanna, Riding, Alex, Soon, Elaine, Southwood, Mark, Toshner, Mark R., Treacy, Carmen, Trembath, Richard C., Trowsdale, John, Wills, Mark   +17 more
core   +1 more source

Preparation and characterization of renal cell peptides from fetal rats for their antitumor activity

FEBS Open Bio, EarlyView.
This study aimed to prepare renal cells (RCs) from fetal rats which were digested by enzymes. Candidate peptides RCPs were characterized by capillary HPLC and MS and their bioactivity was predicted using peptideranker. The predicted top 10 bioactive peptides were synthesized.
Zhe Zhang, Yuan Cao, Jing Du, Ying Zhang, Junxia Wang, Ying Yuan, Lianqing Sun   +6 more
wiley   +1 more source

Lack of expression of inhibitory KIR3DL1 receptor in patients with natural killer cell-type lymphoproliferative disease of granular lymphocytes

Haematologica, 2010
Background Natural killer cell-type lymphoproliferative disease of granular lymphocytes is a disorder characterized by chronic proliferation of CD3−CD16+ granular lymphocytes.
Cristina Gattazzo, Antonella Teramo, Marta Miorin, Elisa Scquizzato, Anna Cabrelle, Mirna Balsamo, Carlo Agostini, Elena Vendrame, Monica Facco, Maria Paola Albergoni, Livio Trentin, Massimo Vitale, Gianpietro Semenzato, Renato Zambello   +13 more
doaj   +1 more source

Effector Functions of Natural Killer Cell Subsets in the Control of Hematological Malignancies. [PDF]

, 2015
Treatment of hematological malignant disorders has been improved over the last years, but high relapse rate mainly attributable to the presence of minimal residual disease still persists.
Biassoni, Biron, Björklund, Brodin, Bryceson, Burns, Campbell, Cooley, Cooper, Cooper, Curti, Davies, Di Santo, Di Santo, Farag, Fehniger, Fogler, Foley, Freud, Gasser, Gilfillan, Grimm, Guethlein, Herberman, Huntington, Joncker, Kiessling, Killig, King, Kröger, Lajoie, Lanier, Leong, Ljunggren, Lowe, Lundqvist, Mancusi, McQueen, Miller, Moretta, Moretta, Moretta, Nguyen, Oevermann, Ouyang, Perussia, Phillips, Romagnani, Romee, Rosenberg, Rosenberg, Rosenberg, Ruggeri, Santoni, Stabile, Stabile, Stern, Stringaris, Thielens, Torelli, Trinchieri, Trinchieri, Vago, Valés-Gómez, Venstrom, Vivier, Whitelaw, Zorn   +67 more
core   +1 more source