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Roles of Natural Killer T Cells and Natural Killer Cells in Kidney Injury [PDF]

International Journal of Molecular Sciences, 2019
Mouse natural killer T (NKT) cells and natural killer (NK) cells are innate immune cells that are highly abundant in the liver. In addition to their already-known antitumor and antimicrobial functions, their pathophysiological roles in the kidney have recently become evident.
Takahiro Uchida, Takahiro Uchida, Shuhji Seki, Takashi Oda, Hiroo Kumagai, Seigo Ito, Hiroyuki Nakashima   +6 more
openaire   +3 more sources

T-cell lymphoma in South America and Europe. [PDF]

, 2012
Peripheral T-cell lymphomas are a group of rare neoplasms originating from clonal proliferation of mature post-thymic lymphocytes with different entities having specific biological characteristics and clinical features.
BELLEI, Monica, Cabrera M. E., Chiattone C. S., Connors J. M., de Souza A. C., FEDERICO, Massimo, Foss F. M., Gabùs R., Horwitz S. M., Liang R., LUMINARI, Stefano, Milone J., Montolo S., Pavlovsky A., PESCE, Emanuela Anna, Pileri S. A., Polliak A., Vose J. M., Zinzani P. L., Zoppegno L., Zucca E.   +20 more
core   +1 more source

Natural killer and natural killer T cells in liver fibrosis

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2013
The liver lymphocyte population is enriched with natural killer (NK) cells, which play a key role in host defense against viral infection and tumor transformation. Recent evidence from animal models suggests that NK cells also play an important role in inhibiting liver fibrosis by selectively killing early or senescence activated hepatic stellate cells
Svetlana Radaeva, Bin Gao
openaire   +3 more sources

Ex vivo-expanded highly purified natural killer cells in combination with temozolomide induce antitumor effects in human glioblastoma cells in vitro.

PLoS ONE, 2019
Glioblastoma is the leading malignant glioma with a poor prognosis. This study aimed to investigate the antitumor effects of natural killer cells in combination with temozolomide as the standard chemotherapeutic agent for glioblastoma.
Yoshitaka Tanaka, Tsutomu Nakazawa, Mitsutoshi Nakamura, Fumihiko Nishimura, Ryosuke Matsuda, Koji Omoto, Yoichi Shida, Toshiharu Murakami, Ichiro Nakagawa, Yasushi Motoyama, Hiromichi Morita, Takahiro Tsujimura, Hiroyuki Nakase   +12 more
doaj   +1 more source

Fasting enhances TRAIL-mediated liver natural killer cell activity via HSP70 upregulation. [PDF]

PLoS ONE, 2014
Acute starvation, which is frequently observed in clinical practice, sometimes augments the cytolytic activity of natural killer cells against neoplastic cells. In this study, we investigated the molecular mechanisms underlying the enhancement of natural
Vu T A Dang, Kazuaki Tanabe, Yuka Tanaka, Noriaki Tokumoto, Toshihiro Misumi, Yoshihiro Saeki, Nobuaki Fujikuni, Hideki Ohdan   +7 more
doaj   +1 more source

Natural Killer Cells

, 2014
Natural killer (NK) cells are lymphocytes of the innate immune system. From a functional point of view, they have been well characterized for their ability to control tumors and infections. However, more recent data indicate that NK cells may also play an important immunoregulatory role.
Yenan T. Bryceson, Niklas K. Björkström, Hans-Gustaf Ljunggren, Jenny Mjösberg   +3 more
openaire   +4 more sources

Whole transcriptome analysis reveals dysregulated oncogenic lncRNAs in natural killer/T-cell lymphoma and establishes MIR155HG as a target of PRDM1

Tumor Biology, 2017
Natural killer/T-cell lymphoma is a rare but aggressive neoplasm with poor prognosis. Despite previous reports that showed potential tumor suppressors, such as PRDM1 or oncogenes associated with the etiology of this malignancy, the role of long non ...
Esra Baytak, Qiang Gong, Burcu Akman, Hongling Yuan, Wing C Chan, Can Küçük   +5 more
doaj   +1 more source

Natural Killer Cell Transfer Assay

Bio-Protocol, 2013
Natural Killer (NK) cells are cytotoxic lymphocytes that constitute a major component of the innate immune system. Immunosurveillance of the host by NK cells for malignant and virally-infected cells results in direct cytotoxicity and the production of ...
Lee-Hwa Tai, Christiano Souza, Andrew Makrigiannis, Rebecca Auer   +3 more
doaj   +1 more source

Relative expression of receptors in uterine natural killer cells compared to peripheral blood natural killer cells

Frontiers in Immunology, 2023
One would expect maternal immune cells to attack the invading trophoblast as the placenta is semi-allogenic. However, they appear to cooperate with the trophoblast in disrupting the arterial wall which has been determined in several studies.
Nurul Izza Ismail
doaj   +1 more source

Uterine natural killer cell heterogeneity: Lessons from mouse models [PDF]

, 2020
Natural killer (NK) cells are the most abundant lymphocytes at the maternal-fetal interface. Epidemiological data implicate NK cells in human pregnancy outcomes.
Sojka, Dorothy K
core   +1 more source