Results 71 to 80 of about 749,043 (396)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Favorable impact of natural killer cell reconstitution on chronic graft-versus-host disease and cytomegalovirus reactivation after allogeneic hematopoietic stem cell transplantation

Haematologica, 2014
Natural killer cells are the first lymphocyte subset to reconstitute, and play a major role in early immunity after allogeneic hematopoietic stem cell transplantation.
Vissal David Kheav, Marc Busson, Catherine Scieux, Régis Peffault de Latour, Guitta Maki, Philippe Haas, Marie-Christine Mazeron, Maryvonnick Carmagnat, Emeline Masson, Aliénor Xhaard, Marie Robin, Patricia Ribaud, Nicolas Dulphy, Pascale Loiseau, Dominique Charron, Gérard Socié, Antoine Toubert, Hélène Moins-Teisserenc   +17 more
doaj   +1 more source

Natural killer cell immunotherapy in glioblastoma

Discover Oncology, 2022
Glioblastoma (GBM) is one of the most difficult cancers to treat because GBM has the high therapeutic resistance. Recently, immunotherapies for GBM have been used instead of conventional treatments.
Hamed Hosseinalizadeh, Mehryar Habibi Roudkenar, Amaneh Mohammadi Roushandeh, Yoshikazu Kuwahara, Kazuo Tomita, Tomoaki Sato   +5 more
doaj   +1 more source

Transgenic expression of the Ly49A natural killer cell receptor confers class I major histocompatibility complex (MHC)-specific inhibition and prevents bone marrow allograft rejection. [PDF]

, 1996
Natural killer (NK) cells and some T cells are endowed with receptors specific for class I major histocompatibility complex (MHC) molecules that can inhibit cellular effector functions.
Cado, D, Held, W, RAULET, David H.
core   +1 more source

Evaluating natural killer cell cytotoxicity against solid tumors using a microfluidic model

Oncoimmunology, 2018
Immunotherapies against solid tumors face additional challenges compared with hematological cancers. In solid tumors, immune cells and antibodies need to extravasate from vasculature, find the tumor, and migrate through a dense mass of cells.
J. Ayuso, Regan Truttschel, Max M Gong, Mouhita Humayun, M. Virumbrales-Muñoz, Ross A Vitek, M. Felder, S. Gillies, P. Sondel, K. Wisinski, M. Patankar, D. Beebe, M. Skala   +12 more
semanticscholar   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Natural killer cell deficiency [PDF]

Journal of Allergy and Clinical Immunology, 2013
Natural killer (NK) cells are part of the innate immune defense against infection and cancer and are especially useful in combating certain viral pathogens. The utility of NK cells in human health has been underscored by a growing number of persons who are deficient in NK cells and/or their functions. This can be in the context of a broader genetically
openaire   +2 more sources

Multifunctional human CD56low CD16low natural killer cells are the prominent subset in bone marrow of both healthy pediatric donors and leukemic patients

Haematologica, 2015
We phenotypically and functionally characterized a distinct CD56low natural killer cell subset based on CD16 expression levels in bone marrow and peripheral blood of healthy children and pediatric patients with acute lymphoblastic leukemia.
Helena Stabile, Paolo Nisti, Stefania Morrone, Daria Pagliara, Alice Bertaina, Franco Locatelli, Angela Santoni, Angela Gismondi   +7 more
doaj   +1 more source

Core binding factors are necessary for natural killer cell development, and cooperate with Notch signaling during T cell specification [PDF]

, 2008
CBF{beta} is the non-DNA binding subunit of the core binding factors (CBFs). Mice with reduced CBF{beta} levels display profound, early defects in T but not B cell development.
Adler, Agosti, Aster, Balciunaite, Barton, Bhandoola, Bories, Burns, Cai, Carlyle, Carlyle, Carotta, Dallas, Davis, de Bruijn, Deftos, DeHart, Di Santo, Douagi, Egawa, Egawa, Ellen V. Rothenberg, Eyquem, Franco, Georgopoulos, Gomez-Lozano, Growney, Han, Heemskerk, Held, Ichikawa, Ikawa, Ivan Maillard, Kee, Kovanen, Krutzik, Kumano, Lacorazza, Lebestky, Lebestky, Maillard, Maillard, Massa, Masuda, McLarren, Moore, Moriggl, Mukouyama, Muthusamy, Nakagawa, Nancy A. Speck, North, Ohno, Okamura, Ono, Pear, Peschon, Pui, Radtke, Robert-Moreno, Rodewald, Rothenberg, Saleh, Sambandam, Sankhamala Chakraborti, Schmitt, Schmitt, Taghon, Talebian, Taniuchi, Van De Wiele, Vosshenrich, Wang, Wilson, Wilson, Yalin Guo, Yokota   +76 more
core   +3 more sources

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source