Results 81 to 90 of about 749,043 (396)

Natural Killer Cells in the Lungs

Frontiers in Immunology, 2019
The lungs, a special site that is frequently challenged by tumors, pathogens and other environmental insults, are populated by large numbers of innate immune cells. Among these, natural killer (NK) cells are gaining increasing attention. Recent studies have revealed that NK cells are heterogeneous populations consisting of distinct subpopulations with ...
Jingjing Cong, Jingjing Cong, Jingjing Cong, Haiming Wei, Haiming Wei   +4 more
openaire   +4 more sources

Modulation of Natural Killer Cell Cytotoxicity in Human Cytomegalovirus Infection: The Role of Endogenous Class I Major Histocompatibility Complex and a Viral Class I Homolog [PDF]

, 1998
Natural killer (NK) cells have been implicated in early immune responses against certain viruses, including cytomegalovirus (CMV). CMV causes downregulation of class I major histocompatibility complex (MHC) expression in infected cells; however, it has ...
Bjorkman, Pamela J., Chapman, Tara L., Formankova, Danuska, Lanier, Lewis L., Leong, Clement C., Mocarski, Edward S., Phillips, Joseph H.   +6 more
core   +2 more sources

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Natural Killer Cells in Psoriasis [PDF]

Journal of Innate Immunity, 2011
Psoriasis is one of the most common immune-mediated disorders. There is evidence that it is mediated by Th1 and, more recently, Th17 cells. The cytokine pattern, particularly the dominance of TNF-α, implicates the innate immune system in psoriasis pathogenesis. Of the many components of the innate immune system known to be involved in psoriatic lesions,
Brian Kirby, Cliona O'Farrelly, Lydia Lynch, Anne-Marie Tobin   +3 more
openaire   +3 more sources

Natural killer cell-derived exosome-based cancer therapy: from biological roles to clinical significance and implications

Molecular Cancer
Natural killer (NK) cells are important immune cells in the organism and are the third major type of lymphocytes besides T cells and B cells, which play an important function in cancer therapy.
Chaohua Si, Jianen Gao, Xu Ma
doaj   +1 more source

Inhibition of bromodomain and extra-terminal (BET) proteins increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells. role of cMYC-IRF4-miR-125b interplay [PDF]

, 2016
Background: Anticancer immune responses may contribute to the control of tumors after conventional chemotherapy and different observations have indicated that chemotherapeutic agents can induce immune responses resulting in cancer cell death and immune ...
Abruzzese, MARIA PIA, Bilotta, MARIA TERESA, Borrelli, Cristiana, Cippitelli, Marco, Fionda, Cinzia, Molfetta, Rosa, Paolini, Rossella, Petrucci, MARIA TERESA, Ricciardi, Maria Rosaria, Santoni, Angela, Soriani, Alessandra, Vulpis, Elisabetta, Zingoni, Alessandra, Zitti, Beatrice   +13 more
core   +13 more sources

Heterogeneity of human bone marrow and blood natural killer cells defined by single-cell transcriptome

Nature Communications, 2019
Natural killer (NK) cells are critical to both innate and adaptive immunity. However, the development and heterogeneity of human NK cells are yet to be fully defined.
C. Yang, Jason R. Siebert, Robert Burns, Zachary J. Gerbec, Benedetta B Bonacci, Amy Rymaszewski, Mary J. Rau, Matthew J. Riese, Sridhar Rao, K. Carlson, J. Routes, J. Verbsky, M. Thakar, S. Malarkannan   +13 more
semanticscholar   +1 more source

Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors.

New England Journal of Medicine, 2020
BACKGROUND Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy has shown remarkable clinical efficacy in B-cell cancers. However, CAR T cells can induce substantial toxic effects, and the manufacture of the cells is complex.
E. Liu, D. Marin, P. Banerjee, H. Macapinlac, P. Thompson, R. Başar, Lucila Nassif kerbauy, Bethany J Overman, P. Thall, Mecit Kaplan, Vandana Nandivada, I. Kaur, A. N. Nunez Cortes, K. Cao, M. Daher, C. Hosing, E. Cohen, P. Kebriaei, R. Mehta, S. Neelapu, Y. Nieto, Michael Wang, W. Wierda, M. Keating, Richard Champlin, E. Shpall, K. Rezvani   +26 more
semanticscholar   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Dynamics of Natural Killer cell receptor revealed by quantitative analysis of photoswitchable protein [PDF]

, 2013
Natural Killer (NK) cell activation is dynamically regulated by numerous activating and inhibitory surface receptors that accumulate at the immune synapse.
Aquino, Gerardo, Davis, Daniel M., Endres, Robert G., Köhler, Karsten, Lagrue, Kathryn, Pageon, Sophie V.   +5 more
core   +2 more sources