Results 81 to 90 of about 9,904,640 (281)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Influence of the provision of natural light and straw bales on activity levels and leg health in commercial broiler chickens

Animal, 2013
The aim of this study was to assess the effect of natural light and straw bales on activity levels and leg health in commercial broiler chickens. Houses containing ∼23 000 broiler chickens were assigned to one of four treatments in a 2 × 2 factorial ...
C.L. Bailie, M.E.E. Ball, N.E. O'Connell
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Young Adults’ Sleep Duration on Work Days: Differences Between East and West

Frontiers in Neurology, 2014
Human sleep schedules vary widely across countries. We investigated whether these variations were related to differences in social factors, morningness-eveningness (ME) preference, or the natural light-dark cycle by contrasting the sleep duration and ...
June Chi-Yan Lo, Ruth Li Fang Leong, Kep Kee eLoh, Derk-Jan eDijk, Michael W L Chee   +4 more
doaj   +1 more source

Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease

Nature Communications, 2020
The SARS-CoV-2 main protease is an important target for the development of COVID-19 therapeutics. Here, the authors combine X-ray crystallography and mass spectrometry and performed a large scale fragment screening campaign, which yielded 96 liganded ...
Alice Douangamath, Daren Fearon, Paul Gehrtz, Tobias Krojer, Petra Lukacik, C. David Owen, Efrat Resnick, Claire Strain-Damerell, Anthony Aimon, Péter Ábrányi-Balogh, José Brandão-Neto, Anna Carbery, Gemma Davison, Alexandre Dias, Thomas D. Downes, Louise Dunnett, Michael Fairhead, James D. Firth, S. Paul Jones, Aaron Keeley, György M. Keserü, Hanna F. Klein, Mathew P. Martin, Martin E. M. Noble, Peter O’Brien, Ailsa Powell, Rambabu N. Reddi, Rachael Skyner, Matthew Snee, Michael J. Waring, Conor Wild, Nir London, Frank von Delft, Martin A. Walsh   +33 more
doaj   +1 more source

Memòria del Parc Natural dels Ports 2024 [PDF]

Gestió efectuada durant el 2024 al Parc Natural dels Ports, destacar les accions estratègiques i les fites més rellevants en cada un dels àmbits i línies de treball.[es] Gestión efectuada durante el 2024 en el Parque Natural de Els Ports, destaca las ...
Parc Natural dels Ports
core  

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

PolyArch

Spool, 2015
The challenge of the future is to minimize the energy consumption of buildings while maintaining an optimal comfort level in the interior. Controlling the energy streams in and out of the building , and especially daylight management, plays an important ...
Eric van den Ham, Truus Hordijk, Tillmann Klein, Jan Hensen, Alexander Rosemann, Albert Schenning, Michael Debije   +6 more
doaj   +1 more source

Memòria del Parc Natural dels Ports 2023 [PDF]

Gestió efectuada durant el 2023 al Parc Natural dels Ports, destacar les accions estratègiques i les fites més rellevants en cada un dels àmbits i línies de treball.[es] Gestión efectuada durante el 2023 en el Parque Natural de Els Ports, destaca las ...
Parc Natural dels Ports
core  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source