Results 111 to 120 of about 8,979,551 (272)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem   +9 more
wiley   +1 more source

Illinois Natural History Survey Annual Report FY2005

open access: yes, 2005
Open Restriction set for Item 105622 on 2018-04-12T19:26:52Z with date null by joellat2@illinois.edu.Submitted by Joella Travis (joellat2@illinois.edu) on 2018-04-12T19:36:10Z No.
Illinois Natural History Survey
core   +1 more source

Posterior Disconnection Syndrome in Early‐Stage Adult‐Onset Cerebral Adrenoleukodystrophy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Adult‐onset cerebral adrenoleukodystrophy is potentially treatable but often difficult to recognize before advanced cerebral involvement. Herein, we describe three men with early‐stage disease who initially presented with subtle visual complaints rather than subcortical dementia. Targeted neuropsychological testing revealed higher‐order visual
Kazuto Katsuse   +13 more
wiley   +1 more source

Anorectal Dysfunction in Systemic Sclerosis: Clinical Phenotypes and Functional Patterns

open access: yesArthritis Care &Research, EarlyView.
Objective The aim of this study was to characterize specific physiologic defects in anorectal dysfunction in systemic sclerosis (SSc) using anorectal manometry (ARM), evaluate associations with gastrointestinal (GI) and extraintestinal clinical phenotypes, and explore potential serologic markers for risk stratification.
Timothy Kaniecki   +6 more
wiley   +1 more source

Programas de luz sobre o desempenho e parâmetros seminais de galos semi-pesados Lightning programs on the performance and seminal parameters of semi-heavy roosters

open access: yesCiência Rural, 2011
Com o objetivo de avaliar a influência de diferentes programas de luz sobre os parâmetros seminais de galos de linhagem semi-pesada, foram utilizados 24 galos da linhagem Lohman Brown com idade inicial de 19 semanas, sendo submetidos a três tratamentos ...
Mônica Patrícia Maciel   +5 more
doaj  

Employment Trajectories of Patients With Systemic Lupus Erythematosus and Factors Driving Transitions Between States

open access: yesArthritis Care &Research, EarlyView.
Objective Systemic lupus erythematosus (SLE) significantly impacts employment capacity. This study aimed to investigate the impact of burden of disease activity, damage, and treatment on employment outcomes and transitions in patients with SLE. Methods Using data from a single center, we analyzed employment transitions, adjusted mean disease activity ...
Javier Mencia‐Ledo   +4 more
wiley   +1 more source

The role of environmental quality factors in decreasing behavioural disorders among pre-school children

open access: yesPayesh, 2013
Objective (s): In recent years there are special attention to the issue of children's education and learning spaces. Unfortunately, in Iran most schools and kindergartens are established without proper design or in non-educational buildings.
Esmaeil Zarghami   +3 more
doaj  

dynoGP: Deep Gaussian Processes for Dynamic System Identification

open access: yesInternational Journal of Adaptive Control and Signal Processing, EarlyView.
This work introduces a novel class of deep models for system identification, dynamical deep Gaussian processes, which combine the strengths of data‐driven methods, such as those based on neural network architectures, with the ability to output a probability distribution for uncertainty representation.
Alessio Benavoli   +3 more
wiley   +1 more source

The Nature of Light [PDF]

open access: yesProceedings of the National Academy of Sciences, 1926
openaire   +2 more sources

On the nature of light

open access: yes
Electromagnetism is at the heart of the Standard Model, but despite all the successes of modern theory, our basic description of light traveling in free space remains unsatisfactory. The four bosons that compose light are introduced in a rather trivial way, simply by quantizing the (scalar and vector) potential amplitudes.
openaire   +2 more sources

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