Results 111 to 120 of about 12,793,653 (323)

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Diferentes substratos e ambientes no enraizamento in vitro de mirtilo Different substrates and environment conditions on in vitro rooting of blueberry

Ciência Rural, 2009
O objetivo neste trabalho foi comparar a capacidade de enraizamento in vitro de mirtilo (Vaccinium ashei Reade cv. 'Delite' e V. corymbosum L. cv. 'Georgiagem') e estudar o efeito de substratos alternativos ao ágar (perlita, vermiculita e ágar + carvão ...
Cláudia Roberta Damiani, Márcia Wulff Schuch   +1 more
doaj   +1 more source

Natural supersymmetry without light Higgsinos

Physical Review D, 2015
22 pages, 2 figures; v2: references ...
Cohen, Timothy, Kearney, John, Luty, Markus   +2 more
openaire   +3 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Cartesian naturalism: natural science in the Meditations

Cogent Arts & Humanities
In a letter to the translator accompanying the French translation of the Principles of Philosophy, Descartes presents a clearly foundationalist view of learning. In this perspective, the ultimate basis of all learning is metaphysics (the first philosophy)
Yasuhiko Tomida
doaj   +1 more source

Influence of the provision of natural light and straw bales on activity levels and leg health in commercial broiler chickens

Animal, 2013
The aim of this study was to assess the effect of natural light and straw bales on activity levels and leg health in commercial broiler chickens. Houses containing ∼23 000 broiler chickens were assigned to one of four treatments in a 2 × 2 factorial ...
C.L. Bailie, M.E.E. Ball, N.E. O'Connell
doaj   +1 more source

Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease

Nature Communications, 2020
The SARS-CoV-2 main protease is an important target for the development of COVID-19 therapeutics. Here, the authors combine X-ray crystallography and mass spectrometry and performed a large scale fragment screening campaign, which yielded 96 liganded ...
Alice Douangamath, Daren Fearon, Paul Gehrtz, Tobias Krojer, Petra Lukacik, C. David Owen, Efrat Resnick, Claire Strain-Damerell, Anthony Aimon, Péter Ábrányi-Balogh, José Brandão-Neto, Anna Carbery, Gemma Davison, Alexandre Dias, Thomas D. Downes, Louise Dunnett, Michael Fairhead, James D. Firth, S. Paul Jones, Aaron Keeley, György M. Keserü, Hanna F. Klein, Mathew P. Martin, Martin E. M. Noble, Peter O’Brien, Ailsa Powell, Rambabu N. Reddi, Rachael Skyner, Matthew Snee, Michael J. Waring, Conor Wild, Nir London, Frank von Delft, Martin A. Walsh   +33 more
doaj   +1 more source

Closing the stop gap

, 2014
Light stops are a hallmark of the most natural realizations of weak-scale supersymmetry. While stops have been extensively searched for, there remain open gaps around and below the top mass, due to similarities of stop and top signals with current ...
Czakon, Michal, Mitov, Alexander, Papucci, Michele, Ruderman, Joshua T., Weiler, Andreas   +4 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Young Adults’ Sleep Duration on Work Days: Differences Between East and West

Frontiers in Neurology, 2014
Human sleep schedules vary widely across countries. We investigated whether these variations were related to differences in social factors, morningness-eveningness (ME) preference, or the natural light-dark cycle by contrasting the sleep duration and ...
June Chi-Yan Lo, Ruth Li Fang Leong, Kep Kee eLoh, Derk-Jan eDijk, Michael W L Chee   +4 more
doaj   +1 more source