Results 61 to 70 of about 9,904,640 (281)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Natural light as a determinant of the identity of architectural space

Journal of Architecture and Urbanism, 2014
In this study, the effect of natural light on the architectural space quality was examined. Contribution of natural light in three different dimensions as the readability of the space, the effect of the space, and its aesthetical evaluation was taken ...
Ilker Fatih Ozorhon, Turkan Ulusu Uraz
doaj   +1 more source

Influence on Learning Efficiency from natural light in Educational Environment [PDF]

, 2018
This paper presents preliminary research outcomes from applying EEG Mind Wave Mapping methodology for investigating the impacts of learning environment on students' concentration and learning performance under different lighting conditions.
Blyth, A., Lau, B., Chen, Y., Yi-Kai, J., Schiano-Phan, R.   +4 more
core  

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Efficient Daylighting: The Importance of Glazing Transmittance and Room Surface Reflectance

Buildings
This study quantitatively analyzes the influence of the spectral characteristics, reflectance or transmittance, of different materials on the lighting of an interior space with natural and artificial light. For this purpose, a three-dimensional simulated
Isabel Escobar, Elvira Orduna-Hospital, Justiniano Aporta, Ana Sanchez-Cano   +3 more
doaj   +1 more source

The Role of Daylight for Humans: Gaps in Current Knowledge

Clocks & Sleep, 2020
Daylight stems solely from direct, scattered and reflected sunlight, and undergoes dynamic changes in irradiance and spectral power composition due to latitude, time of day, time of year and the nature of the physical environment (reflections, buildings ...
Mirjam Münch, Anna Wirz-Justice, Steven A. Brown, Thomas Kantermann, Klaus Martiny, Oliver Stefani, Céline Vetter, Kenneth P. Wright Jr, Katharina Wulff, Debra J. Skene   +9 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source