Results 51 to 60 of about 2,600 (213)

King's Park as an Indigenous Park a Natural History Appraisal

The Western Australian Naturalist, 1957
(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
openaire   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Population dynamics of introduced flathead catfish in Lake Mitchell, South Dakota

Journal of Freshwater Ecology, 2017
The introduction of flathead catfish (Pylodictis olivaris) into Lake Mitchell presented a unique opportunity to study the population dynamics of this species in a South Dakota impoundment.
David O. Lucchesi, Matthew D. Wagner, Tanner M. Stevens, B. D. S. Graeb   +3 more
doaj   +1 more source

Patrimonialisation des reliefs dans les parcs naturels de la façade atlantique européenne

Géographie et Cultures, 2008
Cet article est consacré à l’étude du processus de patrimonialisation des reliefs en Europe et particulièrement dans les parcs naturels de la façade atlantique.
Claire Portal
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Evaluating the Sustainable Development Level of Local Communities Within Hunan Nanshan National Park, China

Land
National parks play a crucial role in promoting the achievement of the Sustainable Development Goals (SDGs) and have become one of the key topics of global concern and discussion.
Lu Bai, Yan Chen, Yaping Cui, Chunting Feng, Chen Wu, Bingran Ma, Weiyang Zhao, Chenxingyu Duan, Wei Wang   +8 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

CROSS-BORDER NATIONAL PARKS IN EUROPE - PRESENT AND PERSPECTIVE - [PDF]

Analele Universității din Craiova. Seria Geografie, 2007
The development of the protected areas system in Europe led to collaborations among the administrations of the national parks in different countries. This was imposed by extension of the natural units that need to be protected even beyond the borderline ...
Laura STUMBEA
doaj