Results 101 to 110 of about 22,798 (265)

A Non‐Canonical Role of SMAD4 in Regulating 3D Genome Architecture to Inhibit Lung Squamous Cell Carcinoma Development

Advanced Science, EarlyView.
SMAD4 is identified as a guardian of 3D genome architecture in lung squamous cell carcinoma. Loss of SMAD4 unleashes EP300 at chromatin loop anchors, strengthening enhancer–promoter looping and H3K27ac at the SOX2 locus to drive aberrant SOX2 activation and tumor cell proliferation.
Qian Tang, Chen Lian, Xinyan Han, Xuhan Zhang, Zihan Wang, Boyu Wang, Taoyu Zhu, Xinrui Lin, Xiaolei Wang, Yaping Xu, Manyu Xiao, Zijin Wang, Junming Li, Silin Chen, Yunze Wang, Yufei Liu, Songsong Li, Zuolin Shen, Xi Lu, Xueqi Han, Yilu Zhou, Mingyang Xiao, Jiayi Ran, Xiaoran Cao, Xinyi Xu, Hugo Sámano‐Sánchez, Alfredo Rodríguez, Lian Wang, Shuifang Chen, Zhanyu Xu, Shirong Zhang, Nuo Yang, Yong Tang, Jian Liu   +33 more
wiley   +1 more source

AGGREGATE STABILITY OF AN ULTISOL IN REGIONS OF THE BRAZILIAN AMAZON

Revista de Agricultura Neotropical
The aggregate stability is essential for water infiltration, soil aeration and root penetration resistance, impacting water infiltration, moisture retention, soil aeration and root penetration resistance. Inadequate agricultural practices can limit root
Diego Lima de Souza Cruz, José Frutuoso do Vale Júnior, Leandro Timoni Buchdid Camargo Neves, Jessica Milanez Tosin Lima, Laís de Brito Carvalho, Ozimar de Lima Coutinho   +5 more
doaj   +1 more source

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

In Situ Pseudo‐Halide Diffusion Enables Buried Interface Regulation and Crystallinity Enhancement in Perovskite Solar Cells

Advanced Science, EarlyView.
Thermally activated LiHCOO induces in situ pseudo‐halide diffusion, promoting buried interface strain release and perovskite crystallization. The monoclinic LiHCOO phase forms an open framework structure that enhances HCOO− diffusion and drives interfacial restructuring.
Chao Gao, Li He, Changjiang Li, Long Fang, Wenzhong Shen   +4 more
wiley   +1 more source

Selenophene π‐Bridge Enables Balanced Ambipolar Transport in High‐Performance Organic Electrochemical Transistors

Advanced Science, EarlyView.
We synthesized a high‐performance balanced ambipolar OECT polymer, P(gTDPPSe), via selenophene π‐bridge engineering. The selenophene π‐bridge enhances backbone planarity and optimizes the energy levels for doping, enabling high and balanced p/n‐type transconductance‐a key factor for high‐gain complementary inverters.
Guichuan Zhu, Yueping Lai, Jiaxing Pu, Jianhua Chen, Liang‐Wen Feng   +4 more
wiley   +1 more source

Dynamic Evolution‐Controlled Parabolic‐Shaped Microstructures for Ultra‐Black Surface via Self‐Assembled Microsphere Mask Etching

Advanced Science, EarlyView.
A robust, substrate‐independent fabrication approach overcomes the spectral and geometric limitations of traditional stray‐light suppression. By combining ink spray‐coating with self‐assembled microsphere mask etching, this method produces parabolic‐shaped microstructures on diverse planar and curved engineering components.
Yiming Li, Jianwei Wang, Guoxu Yu, Qunbo Lv, Yuan Ma, Jiadao Wang   +5 more
wiley   +1 more source

A Conserved DT2‐bZIP66‐NF‐YC4 Regulatory Module Confers Drought Tolerance in Rice and Arabidopsis

Advanced Science, EarlyView.
This study identifies a conserved tripartiteDT2–bZIP66–NF‐YC4 transcriptional module that enhances rice drought tolerance by activating stress‐responsive genes. This regulatory complex is functionally conserved across cereals and Arabidopsis, providing promising targets for engineering drought‐resilient crops. ABSTRACT Drought stress severely restricts
Jun Shen, Yuchen Li, Liang Zhang, Xiaosong Ma, Chenyin Peng, Chunting Yuan, Yu Wu, Kaiyu Zhao, Sheng Zhao, Jiazhuo Guo, Run Li, Ziqian Yan, Shule Ren, Yige Han, Xin Lin, Xinyue Li, Ming Li, Pingfang Yang, Shiyong Song   +18 more
wiley   +1 more source

A Modular PLUG‐IN Photosynthetic Chassis With Tunable Thermal Control for Mammalian Systems

Advanced Science, EarlyView.
This work establishes a “plug‐in” chassis compatible with mammalian systems that synchronizes growth, production, and cell‐wall re‐configuration, providing a versatile platform for photosynthetic bioproduction and microalgal synthetic biology. ABSTRACT Microalgae are promising photosynthetic platforms for high‐value compounds, yet their industrial use ...
Qinhua Gan, Zheng Li, Yunfei Chen, Mingting Du, Qianyi Wu, Congcong Miao, Tao Xu, Shan Wu, Xitao Chen, Xingwei Huang, Yuhui Cheng, Chengcheng Li, Yi Xin, Yandu Lu   +13 more
wiley   +1 more source

Amplitude no fósforo microbiano em um Argissolo em pastagem nativa submetida à roçada e à introdução de espécies forrageiras com fertilização fosfatada em diferentes épocas = Microbial phosphorus fluctuation in a Hapludalf under natural pasture, with cut off and forage species introduction, fertilized in different times

Acta Scientiarum. Agronomy, 2008
Em solos com elevado grau de intemperismo, a imobilização temporária de fósforo pela biomassa microbiana do solo (BMS) pode ser um mecanismo de retardamento das reações de adsorção.
Danilo dos Santos Rheinheimer, Rosane Martinazzo, Luciano Colpo Gatiboni, João Kaminski, Leandro Souza da Silva   +4 more
doaj  

A Biomimetic Dual‐Targeting Nano‐APA‐Editor Reprograms the 3'UTR Landscape for Tongue Squamous Cell Carcinoma Therapy

Advanced Science, EarlyView.
This study unveils a pathogenic axis in oral cancer where NUDT21 suppresses a tumor suppressor network, prominently PTEN, via 3'UTR lengthening. To exploit this transcriptomic vulnerability, we developed a biomimetic Nano‐APA‐editor. By delivering CRISPR/Cas9, we reprogrammed the global 3'UTR landscape, restoring multi‐target tumor suppression and ...
Yiran Ao, Bin Gu, Hui Zhao, Kun Tan, Qin Zhao, Zhengjun Shang   +5 more
wiley   +1 more source