Results 91 to 100 of about 161,791 (305)

Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy

Advanced Science, EarlyView.
A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann, Martijn Dijkstra, Philipp Salomon, Jamie Cowles, Anja Federa, Dina Baier, Carola Jaunecker, Iemima Semerean, Venla Karvonen, Christine Pirker, Maria Sibilia, Dietmar Herndler‐Brandstetter, Petra Heffeter, Bernhard K. Keppler, Christian R. Kowol, Walter Berger   +15 more
wiley   +1 more source

Natural pastures on the outskirts of Lomé in Togo: Diversity, typology and forage quality

Revue Marocaine des Sciences Agronomiques et Vétérinaires, 2018
Ecological and botanical data analysis allow to evaluate state and quality of natural pastures on the outskirts of Lomé. Phytosociological and ecological surveys were conducted on 43 plots.
Marra DOURMA, Laza RANDRANTOARIMBOLA, Yao Agbelessessi WOEGAN, Madjouma KANDA, Semihinva AKPAVI, Koffi AKPAGANA   +5 more
doaj  

Sulfakinin Signaling Sense Circulating Fructose and Suppresses Food Consumption via Insulin‐Like Peptide in Bactrocera Dorsalis

Advanced Science, EarlyView.
This study discovered a new pathway that tells fruit flies when to stop eating. It found that rising blood sugar (fructose) is detected by a sensor called GR43a. This triggers a chain reaction involving the satiety signal sulfakinin and its receptor, ultimately activating a final satiety signal, ILP5.
Hong‐Fei Li, Bao Dong, Zheng‐Lin Ren, Xue‐Guang Zhu, Quan Lei, Yoonseong Park, Jin‐Jun Wang, Hong‐Bo Jiang   +7 more
wiley   +1 more source

Състояние на естествените пасищни тревостои в Странджа планина при различни местонахождения. ІІ. Продуктивност

Почвознание, агрохимия и екология, 2013
The dominant half-upland relief in Strandzha region is determined the structure of land-use. The perspective objects of the communities are orientate to augmentation of the meadow and pasture areas, who to service for the stock-breeding development in ...
КЕРА СТОЕВА, ВИОЛЕТА ВЪТЕВА   +1 more
doaj  

Phosphorus supplementation of Karakul sheep grazing natural pasture

South African Journal of Animal Science, 2016
No ...
Faure, AS, Minnaar, GJ, Burger, FJJ
openaire   +1 more source

Annual and seasonal changes in mineral contents (Ca, Mg, P, K and Na) of grazed clover-grass mixtures in organic farming [PDF]

, 2006
A grazed field experiment was established in 1995 to evaluate alsike clover (Trifoliun hybridum L.), red clover (Trifolium pratense L.) and white clover (Trifolium repens L.) in clover-grass mixtures under organic farming practices.
Kuusela, Eeva
core   +2 more sources

2D Copper MOF Membranes with Precise Pores for Ionic Memory

Advanced Science, EarlyView.
 . ABSTRACT Biological ion channels play a critical role in the complex physiological processes of living organisms. Inspired by these natural systems, we demonstrate the fabrication of ultrathin 2D copper‐based metal‐organic framework (CuMOF) films and their application to mimic key functionalities of biological membranes. Using a liquid–air interface
Hiran Jyothilal, Raj Kumar Gogoi, Yuchen Liu, Vikas Sharma, Solleti Goutham, Michael Hutton, Rachel C. Kilbride, Daniel T.W. Toolan, Ashok Keerthi, Boya Radha   +9 more
wiley   +1 more source

ETV4 Promotes Colorectal Cancer Progression by Reprogramming Asparagine Metabolism to Remodel the Stromal Microenvironment

Advanced Science, EarlyView.
ETV4 coordinates a dual transcriptional program by upregulating MET and asparagine synthetase (ASNS). The resulting asparagine (Asn) secretion acts as a metabolic signal, reprogramming hepatic stellate cells (HSCs) and primary cancer‐associated fibroblasts (CAFs) toward an inflammatory phenotype. These activated stromal cells release HGF to sustain the
Dujiang Fu, Meijia Zhang, Maoping Cai, Miao Wang, Ziao Huang, Zesheng Lin, Yixin Liu, Wang Qian, Guopeng Chen, Yuxing Liang, Dongyi Wei, Jing xie, Picheng Yan, Yuanyuan Qu, Yongchang Wei   +14 more
wiley   +1 more source

Bedeutung der Megaherbivoren-Beweidung für die Renaturierung artenreicher Feuchtgrünländer auf ehemaligen Ackerflächen [PDF]

, 2013
Species-rich wet grasslands in floodplains are on focus of European nature conservation policy. However, since the seventies of the last century large areas with grasslands in floodplains have been meliorated, ploughed and used for intensive cropping in ...
Mann, Sandra, Tischew, Sabine
core  

Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk

Advanced Science, EarlyView.
Integration of a pancreatic eQTL map with a GWAS meta‐analysis identifies 82 putative functional variants and 15 genes. The association between rs11102484 and pancreatic cancer risk is observed in a total of 5699 cases and 8467 controls. The G allele of rs11102484 weakens ZNF263 binding and the silencer‐promoter interaction, thereby increasing ST7L ...
Xiaoyang Wang, Hui Geng, Zhengyan Yao, Yuan Jiang, Can Chen, Zequn Lu, Shuangshuang Tian, Ming Zhang, Ruiyan Liu, Chenxi Feng, Bin Li, Xiaoping Miao, Jianbo Tian, Shaokai Zhang, Ying Zhu   +14 more
wiley   +1 more source