Results 81 to 90 of about 22,798 (296)

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

open access: yesAdvanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng   +8 more
wiley   +1 more source

Development of semi-natural horse pastures in Ypäjä

open access: yes, 2004
The purpose of the study is to assess the importance of natural pastures as a growing environment for horses and, at the same time, to evaluate the landscape value of such pastures.
Jansson, Helena
core  

Pastures at Shannon Vale nutrition station [PDF]

open access: yes, 1962
Selected sown and natural pastures on the granitic soils of Shannon Vale Nutrition Station were compared over a period of 3½ years, 1951-54. Dry matter, botanical composition, and protein yields were assessed at each of 14 consecutive sampling periods of
Walker, Milton Hunter
core  

Perspective: Hollow Core Optical Fibres for Ultraviolet and Visible Wavelengths

open access: yesAdvanced Science, EarlyView.
Hollow core optical fibres bypass material constraints that limit optical fibres at ultraviolet and visible wavelengths. However, their challenging fabrication has limited their development, and significant gains in performance remain possible. In this perspective we outline approaches to enable the next generation of fibres for shorter wavelengths ...
Robbie Mears   +5 more
wiley   +1 more source

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

open access: yesAdvanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu   +10 more
wiley   +1 more source

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

open access: yesAdvanced Science, EarlyView.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi   +23 more
wiley   +1 more source

Effects of herbage intake on goat performance in the mediterranean type natural pastures

open access: yesAnimal Science Journal, 2009
ABSTRACTThis study aimed at identifying changes in natural pastures during the grazing season and investigating the effects of these changes on pasture feeding potential for high yielding dairy goats. During the study, 12 dairy goats were grazed on a 1.5 ha natural pasture for three months from April to June in 2003, 2004 and 2005. The goats were fed 0.
Hakyemez, Basri H.   +3 more
openaire   +4 more sources

Characteristics of the three pastures located at Val Troncea Natural Park (Italy) and used for the farm-scale study.

open access: yes, 2021
Characteristics of the three pastures located at Val Troncea Natural Park (Italy) and used for the farm-scale study.
Michele Lonati (498072)   +3 more
core   +1 more source

Corals and Reef‐Dwelling Fish Regulate Carbon Storage and Cycling Processes in Coral Reef Ecosystems

open access: yesAdvanced Science, EarlyView.
Coral reefs are biodiversity hotspots, yet their role in carbon storage and cycling remains poorly understood. Using field surveys and modeling in the South China Sea, we reveal the overlooked potential of carbon storage in reef ecosystems and how reef fish, corals, and surface sediment jointly shape reef carbon reservoirs.
Yiting Chen   +8 more
wiley   +1 more source

Remote sensing in inventory of high altitude pastures of the eastern Tibetan Plateau

open access: yesRangifer, 2004
The animal husbandry practised on high altitude pastures of the eastern Tibetan Plateau is based on the use of natural pastures. The livestock consists of yaks, sheep and horses.
Timo Kumpula   +3 more
doaj   +1 more source

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