Results 41 to 50 of about 2,753 (252)

Aptamer‐Targeted PrPC Drives Colorectal Cancer Metastasis via a LYN‐STAT3 Complex and Enables Liquid Biopsy Detection

Advanced Science, EarlyView.
The aptamer WHY‐3E identifies PrPC as a CRC driver. Stabilized by USP18, endocytosed PrPC forms a LYN/STAT3 complex, upregulating MSN transcription to promote metastasis. Crucially, WHY‐3E sensitively detects PrPC‐positive circulating exosomes, establishing a robust theoretical foundation for non‐invasive clinical diagnostics.
Chunlin Wang, Hongyu Wu, Chaojing Zheng, Hao Zhang, Xiaoqiu Wu, Jiaqi Wang, Zewen Chang, Jun Xiang, Yunxiao Liu, Chenkai Zhang, Yuliuming Wang, Hao Jiang, Yuchen Zhong, Jun Luo, Ying Chen, NaNa Zhang, Weiyuan Zhang, Ziming Yuan, ChaoXia Zou, Weihong Tan, Meng Wang, Hanqing Hu, Tao Bing, Guiyu Wang   +23 more
wiley   +1 more source

Prediction of indicators about transboundary natural plague foci in the Balkhash-Alakol deposition of Kazakhstan and the Dzungarian basin of China [PDF]

Caspian Journal of Environmental Sciences
The Kazakhstan-China territorial border has vast swathes (1782.75 km), where transboundary natural plague foci are located and where the "Great Silk Road" used to pass.
Abdel Ziyat Zhumadiluly, Zhumadilova Zauresh Bapanovna, Meka-Mechenko Tatyana Vladimirovna, Abdirassilova Aigul Agsamovna, Issaeva Svetlana Berdimuratovna, Mussagalieva Raikhan Safarovna, Shakiyev Nurbol Nauryzuly   +6 more
doaj   +1 more source

PDIA6–SCD1 Axis Rewires Lipid Metabolism to Drive Gastric Cancer Progression

Advanced Science, EarlyView.
Protein disulfide isomerase A6 (PDIA6) is identified as an oncogenic driver in gastric cancer. PDIA6 directly binds and stabilizes SCD1 by limiting its ubiquitin–proteasome‐mediated degradation, thereby sustaining monounsaturated fatty acid (MUFA)‐enriched lipid homeostasis and lipid metabolic reprogramming.
Zhen Tian, Yifan Cheng, Jiajie Zhou, Ruiqi Li, Shuai Zhao, Ben Li, Zijie Xu, Mengli Zi, Yayan Fu, Chenkai Zhang, Qiannan Sun, Shantanu Baral, Sen Wang, Daorong Wang   +13 more
wiley   +1 more source

Analysis of the Global Plague Epidemiological Situation in 2025 and a Forecast of the Epizootic Activity of Its Natural Foci in the Russian Federation for 2026

Проблемы особо опасных инфекций
The aim of this study was to analyze the global plague epidemiological situation in 2025 and forecast the epizootic activity of natural foci of this particularly dangerous infection in the Russian Federation for 2026.
N. V. Popov, I. G. Karnaukhov, A. M. Matrosov, A. V. Ivanova, A. A. Kuznetsov, A. M. Porshakov, M. V. Pospelov, Ya. A. Neishtadt, V. M. Korzun, D. B. Verzhutsky, E. V. Chipanin, A. V. Kholin, A. A. Lopatin, V. M. Dubyansky, U. M. Ashibokov, A. Yu. Gazieva, I. V. Kutyrev, S. V. Balakhonov, A. N. Kulichenko, V. V. Kutyrev   +19 more
doaj   +1 more source

T2T Genome Assembly and Multi‐Omics Data Reveal Terrestrial Adaptation and Mucus Biosynthesis in Tropical Leatherleaf Slug (Laevicaulis alte)

Advanced Science, EarlyView.
A gap‐free genome assembly and multi‐omics comparison of the terrestrial slug Laevichaulis alte with an aquatic relative reveal that expansion of the VEGF family orchestrates mucus production, lipid metabolism, and immune defense—highlighting key molecular innovations for conquering life on land.
Gang Wang, Shaofang He, Zhongkai Wang, Aobo Pang, Xiaoli Sun, Rongchen Liu, Fang Wang, Sisi Chen, Zhijuan Bian, Dongcheng Wei, Liuhan Wu, Siyao Zhao, Qiuting Ji, Yiqi Sun, Niying Sun, Yushinta Fujaya, Boping Tang, Kianann Tan, Daizhen Zhang, Lianfu Chen   +19 more
wiley   +1 more source

Analysis of the Current Epidemiological Situation in Natural Plague Foci around the World. Enhancement of the Effectiveness of Epidemiological Surveillance in Natural Plague Foci of the Russian Federation and Forecast of their Epizootic Activity for 2019

Проблемы особо опасных инфекций, 2019
The paper presents the analysis of epidemic activity of natural plague foci around the world, including in CIS and the Russian Federation, over the period of 2000–2018.
N. V. Popov, I. G. Karnaukhov, N. D. Pakskina, G. A. Eroshenko, A. A. Kuznetsov, A. N. Matrosov, A. M. Porshakov, E. V. Kouklev, A. V. Ivanova, V. M. Korzun, S. A. Kosilko, E. S. Zenkevich, V. P. Popov, A. A. Lopatin, T. Z. Ayazbaev, S. V. Balakhonov, V. V. Kutyrev   +16 more
doaj   +1 more source

Tandem Duplication‐Driven Neofunctionalization of UDP‐Glycosyltransferases Shapes the Diversification of Triterpenoid Saponins in the Cucurbitaceae

Advanced Science, EarlyView.
We present a chromosome‐level genome assembly of Siraitia grosvenorii and, through comparative genomics, uncover a conserved UGT73 tandem array driving triterpenoid saponin diversification in Cucurbitaceae. Crystalized SgUGT73AM30 further reveals the regioselectivity mechanism underlying its catalytic activity.
Guangyi Wang, Mengmeng Li, Xuehui Dai, Yanchen Zhang, Yuhan Wu, Zhaotao Yan, Chenfei Tian, Hongkai Fan, Haili Liu, Xiaowei Zhang, Yiming Yang, Jiayu Lu, Yuwei Sun, Yong Wang   +13 more
wiley   +1 more source

Principles of Management of the Epizootiologic Monitoring of Combined Natural Foci of Plague and Other Dangerous Infectious Diseases in the Lower-Volga Region

Проблемы особо опасных инфекций, 2009
Based on the experience of the long-term epizootiologic survey in the natural foci of plague, determined were the principles of usage of the developed methodology of monitoring of the dangerous infectious diseases combined with plague.
A. A. Kuznetsov, A. N. Matrosov, V. P. Ossipov, T. V. Knyazeva, A. M. Porshakov, N. V. Popov, E. V. Kouklev, S. A. Scherbakova, V. P. Toporkov   +8 more
doaj   +1 more source

Multi‐tissue Metabolic GWAS and Drought‐Responsive Multi‐omics Reveal the Genetic Basis of the Quinoa Metabolome

Advanced Science, EarlyView.
A multi‐omics framework combining multitissue genome‐wide association studies, metabolomics, transcriptomics, proteomics, and functional validation uncovers the genetic basis of specialized metabolism in quinoa. The study identifies hundreds of metabolite‐associated loci, prioritizes candidate genes for saponin, betalain, and flavonoid biosynthesis ...
Julia von Steimker, Elodie L. Rey, Clara Stanschewski, Regina Wendenburg, Annabella Klemmer, Markéta Macho, Venkatesh P. Thirumalaikumar, Noha O. Saber, Aleksandra Skirycz, Alisdair R. Fernie, Mark Tester, Saleh Alseekh   +11 more
wiley   +1 more source

Biomimetic Gradient Hydrogels Regulate Osteochondral Regeneration Microenvironment Remodeling via Spatiotemporal Programming Engineering

Advanced Science, EarlyView.
Electric field‑driven continuous gradient hydrogel GHZF4 achieves spatiotemporal growth factor release, modulates immune microenvironment, angiogenesis and osteochondral differentiation. It realizes cell‑free functional osteochondral repair in rat/rabbit models, offering a promising biomimetic strategy for gradient tissue regeneration.
Xiaolian Niu, Shengzhao Xiao, Di Huang, Xuesong Wang, Yanwei Cao, Xiaodan Sun, Nicholas Dunne, Xiaoming Li   +7 more
wiley   +1 more source