Results 51 to 60 of about 2,753 (252)

Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease

Advanced Science, EarlyView.
Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang, Jiaqi Zhang, Yuzhi Wang, Yaodong Wang, Peng Lin, Yanling Wang, Zixuan Tang, Jintai Yu, Qin Zhou, Feiyun Cui   +9 more
wiley   +1 more source

Postaqual Dry Land of the Aral Sea as Potential Natural Focus of Plague

Проблемы особо опасных инфекций, 2010
Presented are the results of examination of a current condition of the Aral Sea and the adjacent postaqual territory as potential plague focus. Study and comparison of the new territories with the existing natural plague foci in the adjacent territory of
G. R. Bazarova
doaj   +1 more source

[Natural foci of plague in India: epizootological characteristics].

Meditsinskaia parazitologiia i parazitarnye bolezni, 2009
In the first half of the 20th century, India was responsible for the incidence of plague in both Asia and the world. The early 21st century was marked by two new epidemic outbreaks of plague (in 2002 and 2004) in this country. The major characteristics of plagues in India, activation of which is a cause of new epidemic outbreaks and necessitates a ...
L P, Bazanova, A S, Maramovich, A Ia, Nikitin, S A, Kosilko, L P, Okunev, T I, Innokent'eva, G A, Voronova   +6 more
openaire   +1 more source

An Artificially Selected Cytokinin‐Pathway Transcription Factor Balances Soybean Yield and Pathogen Resistance

Advanced Science, EarlyView.
A cytokinin pathway transcription factor, RR2b, was artificially selected during soybean domestication and improvement based on its differential transcriptional activity, which correlates with ATT repeat polymorphisms in its promoter. RR2b balances yield and defense by fine‐tuning its expression level and offers a promising target for decoupling trade ...
Qun Ma, Yaqing Chen, Yiwen Gao, Xueting Hu, Qun Yang, Yucheng Liu, Peiyong Xin, Jijun Yan, Jinfang Chu, Lei Li, Zhixi Tian, Bo Ren   +11 more
wiley   +1 more source

Modern Conception of the Control over the Abundance of Carriers and Vectors of Plague in the Territory of the Russian Federation

Проблемы особо опасных инфекций, 2012
Disinfestation and deratization remain the main ways of non-specific disease prophylaxis in natural plague foci. Modern strategies, tactics, methods and means of control over carriers and vectors of plague and associated infectious diseases are selected ...
A. N. Matrosov, A. A. Kuznetsov, T. V. Knyazeva, D. B. Verzhutsky, A. Ya. Nikitin, L. S. Nemchenko, M. P. Grigor'ev, B. I. Levchenko, O. A. Bobenko, A. Yu. Gazieva, V. B. Korotkov   +10 more
doaj   +1 more source

SOX5 Orchestrates Malignant Evolution via Promoter‐Centric Chromatin Remodeling in MYC‐Driven B‐Cell Lymphoma

Advanced Science, EarlyView.
In MYC‐enforced B‐cell lymphoma, SOX5 occupies promoter‐proximal regulatory regions and is associated with reduced chromatin accessibility at the PCNP locus. PCNP repression promotes proliferative remodeling by limiting apoptosis and cell‐cycle restraint.
Yiyou Mao, Zhenyuan Jia, Xiao‐Qin Mu, Ruilin Wang, Jianli Ma, Qingyuan Zhang, Yuwei Deng   +6 more
wiley   +1 more source

Peculiarities of Spatial Structure of the Central Caucasian High-Mountain Natural Plague Focus

Проблемы особо опасных инфекций, 2013
Within the limits of Central Caucasian high-mountain natural plague focus discovered are two zones of natural focality. The first natural focality zone in the mountain steppe of the eastern part of the focus has a parasitic complex similar in structural ...
Yu. M. Evchenko, A. N. Kulichenko, G. A. Mozloev, V. M. Mezentsev   +3 more
doaj   +1 more source

Soloviov Valentyn Ivanovych, an epizootologist, mammalogist, and ecologist [PDF]

Novitates Theriologicae, 2022
An essay about V. I. Soloviov, a zoologist, epizootologist, head of the zoological laboratory of Odessa Anti-Plague Institute. Valentyn Soloviov studied natural foci of particularly dangerous infections and the role of small mammals and their parasites ...
Svitlana Uzhevska, Dmytro Sokolovsky
doaj  

Overcoming Interfacial Hurdles in Solid‐State Aluminum Batteries for Safe and Energy‐Dense Storage

Advanced Science, EarlyView.
Solid‐state aluminum batteries (SSABs) promise high energy density and intrinsic safety but face severe solid–solid interfacial challenges. This review reveals the three core hurdles—anode passivation, cathode contact loss, and electrolyte grain boundary resistance and discusses strategies including artificial interphases, alloying, and composite ...
Yunlei Wang, Xiaogang Zhang, Mingguang Wang, Yifan Wu, Shitao Dou, Taibin Wu   +5 more
wiley   +1 more source

Persistence of Yersinia pestis in Soil Under Natural Conditions

Emerging Infectious Diseases, 2008
As part of a fatal human plague case investigation, we showed that the plague bacterium, Yersinia pestis, can survive for at least 24 days in contaminated soil under natural conditions.
Rebecca J. Eisen, Jeannine M. Petersen, Charles L. Higgins, David Wong, Craig E. Levy, Paul S. Mead, Martin E. Schriefer, Kevin S. Griffith, Kenneth L. Gage, Charles Ben Beard   +9 more
doaj   +1 more source