Results 191 to 200 of about 13,213,530 (364)

Application of crystalline sponge method and crystallization chaperone technology in the structure elucidation of natural products [PDF]

Yuxin Kan, Yuxuan Zhang, Fujiang Guo, Yiming Li   +3 more
openalex   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

The undiscovered natural product potential of Actinomycetes. [PDF]

J Antibiot (Tokyo)
Caraballo-Rodríguez AM, Cumsille A, Magyari S, Taboada-Alquerque M, Behsaz B, Leão TF, Broders K, El Abiead Y, Clement JA, Charron-Lamoureux V, Zuffa S, Nothias LF, Hu M, Leone C, Kakhkhorov SA, Cámara B, Mohimani H, Dorrestein PC.   +17 more
europepmc   +1 more source

Bioactivity-Based Molecular Networking for the Discovery of Drug Leads in Natural Product Bioassay-Guided Fractionation.

Journal of Natural Products, 2018
Louis-Félix Nothias, Mélissa Nothias-Esposito, R. D. da Silva, Mingxun Wang, Ivan V. Protsyuk, Zheng Zhang, Abinesh Sarvepalli, P. Leyssen, D. Touboul, J. Costa, J. Paolini, T. Alexandrov, M. Litaudon, P. Dorrestein   +13 more
semanticscholar   +1 more source

Discovery of Novel Antiangiogenic Marine Natural Product Scaffolds [PDF]

, 2016
Hassan Y. Ebrahim, Khalid A. El Sayed
openalex   +1 more source

Effectiveness and Safety of Nusinersen and Risdiplam in Spinal Muscular Atrophy: A Systematic Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinal Muscular Atrophy (SMA) is a rare genetic disorder marked by progressive muscle weakness and mobility loss. It has a profound physical, emotional and social impact on patients and caregivers, requiring comprehensive medical and supportive care.
Amin Mehrabian, Peter Auguste, Amy Grove, Anna Brown, Janette Parr, Mubarak Patel, Furqan Butt, Jeremiah Donoghue, Mehdi Yousefi, Jo Parsons   +9 more
wiley   +1 more source

Retraction of "Artificial Intelligence in Natural Product Drug Discovery: Current Applications and Future Perspectives". [PDF]

J Med Chem
Gangwal A, Lavecchia A.
europepmc   +1 more source

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

The Biosynthetic Pathway to the Pyrroloiminoquinone Marine Natural Product Ammosamide C. [PDF]

J Am Chem Soc
Ramos-Figueroa JS, Zhu L, Halliman M, van der Donk WA.   +3 more
europepmc   +1 more source

The structural modification of natural products for novel drug discovery

, 2016
Hong Yao, Junkai Liu, Shengtao Xu, Zheying Zhu, Jinyi Xu   +4 more
openalex   +2 more sources