Results 121 to 130 of about 1,083,042 (374)
MIF as an oncogenic driver of low‐heterogeneity melanomas
Molecular Oncology, EarlyView.Shvefel and colleagues identified tumor‐secreted macrophage migration inhibitory factor (MIF) as an upregulated cytokine that mediates immune resistance in melanomas with low‐intratumoral heterogeneity. MIF and its functional paralogue D‐dopachrome tautomerase (D‐DT or MIF‐2) have overlapping but nonidentical signaling functions and are hypothesized to
Thuy T. Tran +4 more
wiley +1 more source
Marine Natural Products in Medicinal Chemistry [PDF]
ACS Medicinal Chemistry Letters, 2018 An overview of the marine natural products (MNPs) field is shown, including an update of FDA-approved drugs and those in clinical trials that can be considered derivatives of MNPs. The importance of marine microorganisms in present studies and the application of emerging techniques and technologies to this field are highlighted.
openaire +3 more sources
Application of optical rotatory dispersion studies to problems in natural products chemistry [PDF]
, 1961 Carl Djerassi
openalex +1 more source
FEBS Open Bio, EarlyView.Novel mAbs could detect cancer‐associated membrane proteins on various type of pancreatic ductal adenocarcinomas (PDAC) by flow cytometry with viable PDAC cells and by immunohistochemistry with PDAC tissues. Results of protein expression were substantiated by mRNA expression by The Cancer Genome Atlas.
Takashi Nakano +16 more
wiley +1 more source
Heliyon, 2019 Two biologically important molecules specioside (SS) and verminoside (VS) have been isolated from the ethanolic extract of stem bark of Kigelia pinnata.
Monika Saini +5 more
doaj
Do Nonequilibrium Processes Have Features in Common? [PDF]
arXiv, 2007 The nature takes the easiest and most accessible paths and, hence, processes are accomplished very quickly in a minimum time. In 1662 P. Fermat used this principle to work out the refraction law. This was one of the first known attempts at successful deductive description of a physical phenomenon involving the variational principle.
arxiv
Mass Spectrometry in Natural Product Chemistry [PDF]
, 1964 John Harley-Mason
openalex +1 more source
Evaluation of synaptotagmin‐1 action models by all‐atom molecular dynamics simulations
FEBS Open Bio, EarlyView.We used molecular dynamics simulations to test models proposing that synaptotagmin‐1 facilitates membrane fusion by perturbing lipid bilayers, inducing membrane curvature and/or bridging membranes. The simulations show that synaptotagmin‐1 C2‐domains placed near the site of fusion hinder the ability of SNARE complexes to bring the membranes together ...
Josep Rizo +2 more
wiley +1 more source
Chemical synthesis and cytotoxicity of neo-glycolipids; rare sugar-glycerol-lipid compounds
Heliyon, 2018 Rare sugars are defined as monosaccharides and their derivatives, which rarely exist in nature and have various beneficial effects on organisms, biomaterials and foods.
Keisuke Hirata +4 more
doaj
Design for a Darwinian Brain: Part 1. Philosophy and Neuroscience [PDF]
arXiv, 2013 Physical symbol systems are needed for open-ended cognition. A good way to understand physical symbol systems is by comparison of thought to chemistry. Both have systematicity, productivity and compositionality. The state of the art in cognitive architectures for open-ended cognition is critically assessed. I conclude that a cognitive architecture that
arxiv