Results 131 to 140 of about 1,495,910 (392)
A Historical Overview of Natural Products in Drug Discovery
Metabolites, 2012 Historically, natural products have been used since ancient times and in folklore for the treatment of many diseases and illnesses. Classical natural product chemistry methodologies enabled a vast array of bioactive secondary metabolites from terrestrial
Daniel A. Dias +2 more
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The Chemistry of Natural Products related to Phenanthrene [PDF]
, 1937 Louis Fieser
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Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
The crystal structure of a matrine derivative, 13-(4-Cl-pyrrole)-matrine, C18H26ClN4O
Zeitschrift für Kristallographie - New Crystal Structures, 2019 C18H26ClN4O, orthorhombic, P212121 (no. 19), a = 5.3476(1) Å, b = 14.4068(2) Å, c = 22.3285(4) Å, V = 1720.23(5) Å3, Z = 4, Rgt(F) = 0.0328, wRref(F2) = 0.0774, T = 100 K.
Jing-Min Ye +5 more
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Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node
FEBS Open Bio, EarlyView.The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner +6 more
wiley +1 more source
SYNTHETIC APPROACHES TO POLIFUNCTIONALIZED PERHYDRINDANES [PDF]
Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2011 The current communication represents an extended abstract of the presentation delivered on the joint Moldo-Italian seminar “New frontiers in natural product chemistry”, held in the Institute of Chemistry, Academy of Sciences of Moldova on 31 September ...
Veaceslav Kulciţki
doaj
FEBS Open Bio, EarlyView.Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp +13 more
wiley +1 more source
Natural product anticipation through synthesis
Nature Reviews Chemistry, 2022 Belinda E. Hetzler +2 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah +8 more
wiley +1 more source