Results 131 to 140 of about 1,189,605 (351)
FEBS Open Bio, EarlyView.CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee +3 more
wiley +1 more source
A Historical Overview of Natural Products in Drug Discovery
Metabolites, 2012 Historically, natural products have been used since ancient times and in folklore for the treatment of many diseases and illnesses. Classical natural product chemistry methodologies enabled a vast array of bioactive secondary metabolites from terrestrial
Daniel A. Dias +2 more
doaj +1 more source
, 2014 Natural products and their mimics have a high probability of engaging with biological targets. Hence, natural products have historically been a valuable source of medicines.
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A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms
FEBS Open Bio, EarlyView.We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley +1 more source
The crystal structure of a matrine derivative, 13-(4-Cl-pyrrole)-matrine, C18H26ClN4O
Zeitschrift für Kristallographie - New Crystal Structures, 2019 C18H26ClN4O, orthorhombic, P212121 (no. 19), a = 5.3476(1) Å, b = 14.4068(2) Å, c = 22.3285(4) Å, V = 1720.23(5) Å3, Z = 4, Rgt(F) = 0.0328, wRref(F2) = 0.0774, T = 100 K.
Jing-Min Ye +5 more
doaj +1 more source
The Chemistry of Natural Products related to Phenanthrene [PDF]
, 1937 Louis Fieser
openalex +1 more source
HSP70 governs permeability and mechanotransduction in primary human endothelial cells
FEBS Open Bio, EarlyView.HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez +5 more
wiley +1 more source
SYNTHETIC APPROACHES TO POLIFUNCTIONALIZED PERHYDRINDANES [PDF]
Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2011 The current communication represents an extended abstract of the presentation delivered on the joint Moldo-Italian seminar “New frontiers in natural product chemistry”, held in the Institute of Chemistry, Academy of Sciences of Moldova on 31 September ...
Veaceslav Kulciţki
doaj
PENGEMBANGAN KETERAMPILAN GENERIK SAINS, KETERAMPILAN BERPIKIR KRITIS, DAN PEMAHAMAN KONSEP MAHASISWA MELALUI PRAKTIKUM PROYEK MINI KIMIA BAHAN ALAM [PDF]
, 2014 Penelitian ini bertujuan untuk mengembangkan model praktikum kimia bahan alam (KBA) dan meningkatkan keterampilan generik sains (KGS), keterampilan berpikir kritis (KBK), serta pemahaman konsep KBA mahasiswa.
Hakim, Aliefman
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