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The Spinosyns, Spinosad, Spinetoram, and Synthetic Spinosyn Mimics - Discovery, Exploration, and Evolution of a Natural Product Chemistry and the Impact of Computational Tools.

Pest Management Science, 2020
Natural products (NPs) have long been a source of insecticidal crop protection products. Like many macrolide NPs, the spinosyns originated from a soil inhibiting microorganism (Saccharopolyspora spinosa).
T. C. Sparks   +6 more
semanticscholar   +1 more source

Mind the mushroom: natural product biosynthetic genes and enzymes of Basidiomycota.

Natural product reports (Print), 2021
Covering: up to September 2020Mushroom-forming fungi of the division Basidiomycota have traditionally been recognised as prolific producers of structurally diverse and often bioactive secondary metabolites, using the methods of chemistry for research ...
Markus Gressler   +5 more
semanticscholar   +1 more source

Recent developments in the chemistry of ferrocenyl secondary natural product conjugates

Coordination chemistry reviews, 2018
Secondary natural products are a source of an endless inspiration in medicinal chemistry. They are characterized by a complex structure and potent biological activity. Ferrocene is an organometallic compound which is characterized by simple sandwich-like
K. Kowalski
semanticscholar   +1 more source

Marine Natural Product Bis-indole Alkaloid Caulerpin: Chemistry and Biology.

Mini-Reviews in Medical Chemistry, 2019
Marine bis-indole alkaloids comprise a large and increasingly growing class of secondary metabolites, and continue to deliver a great variety of structural templates for diverse biological targets.
Jignesh Lunagariya   +4 more
semanticscholar   +1 more source

The Role of Natural Product Chemistry in Drug Discovery: Two Decades of Progress and Perspectives.

Journal of Natural Products
Natural products (NPs) have long played a pivotal role in medicine, serving as both lead compounds and approved drugs in diverse therapeutic areas. Inspired by the 2004 review "The Role of Natural Product Chemistry in Drug Discovery", we adopted a data ...
Mark S. Butler, J. L. La Clair
semanticscholar   +1 more source

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