Results 31 to 40 of about 10,832 (262)

Attenuating AAV-triggered innate immunity in the adult mouse nervous system via cGAS–STING pathway inhibition

Acta Pharmaceutica Sinica B
While adeno-associated virus (AAV)-mediated gene delivery has emerged as a promising therapeutic modality for neurological disorders, dose-dependent immune responses remain a critical barrier to clinical translation.
Yaowei Guo, Jiehao Huang, Yuqi Zhang, Yuxiang Huang, Zeru Li, Yu Xie, Yingqi Cao, Kun Qian, Fan Bai, Wen Li, Wenliang Lei, Gong Chen, Zheng Wu   +12 more
doaj   +1 more source

Assisted natural regeneration of selected tree species through silviculture interventions as a tool for restoring degraded natural forests in northwestern Ethiopia

Forest Science and Technology, 2023
Natural forest ecosystem assets and services are increasingly deteriorating due to forest degradation and deforestation in Northern parts of Ethiopia.
Melkamu Kassaye, Amsalu Nigatu, Bahiru Gedamu, Yonas Derebe, Mulugeta Tamer, Fentahun Ayne, Etsegenet Emiru, Beyene Belay   +7 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Olig2 acts as an inducible barrier to in vivo astrocyte-to-neuron conversion

Nature Communications
In vivo astrocyte-to-neuron (AtN) conversion suffers low efficiency due to pre-existing intrinsic barriers. However, it is unclear whether astrocytes have inducible barriers to reprogramming.
Chuying Lai, Kaiyu Hou, Wenyu Li, Jiahui Wang, Xiaoman Cai, Ya Shi, Miao Yang, Danting Yu, Kang Lu, Wen Li, Gong Chen, Zheng Wu   +11 more
doaj   +1 more source

Investigations on spatial heterogeneity of humus forms and natural regeneration of Larch (Larix decidua Mill.) and Swiss Stone Pine (Pinus cembra L.) in an alpine timberline ecotone (Upper Engadine, Central Alps, Switzerland) [PDF]

Geographica Helvetica
The north-west facing study area in the Upper Engadine (Central Alps, Switzerland) encompasses the whole timberline ecotone between 2200 m and 2400 m a.s.l..
B. Hiller, A. Müterthies, F.-L. Holtmeier, G. Broll   +3 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Small extracellular vesicles loaded with neurotrophin-3 confer multitargeted therapeutic effects in treating spinal cord injury

Nano Research
Neural repair following spinal cord injury (SCI) remains a significant medical challenge, necessitating effective therapeutic strategies. This study integrates mesenchymal stem cell-derived small extracellular vesicles (sEVs) with neurotrophin-3 (NT3) to
Fuxiang Li, Zhonghai Huang, Jinrui Zhou, Zicong Wu, Xiao-Hui Deng, Huandi Weng, Wanxing Peng, Jing Li, Ye Lin, Kwok-Fai So, Qing-Ling Fu, Libing Zhou   +11 more
doaj   +1 more source

Cost analysis of artificial and natural oak regeneration in selected forest districts

Leśne Prace Badawcze, 2017
The aim of the paper is to present the results of a cost analysis for artificial and natural oak regeneration in selected forest districts in Poland.
Kaliszewski Adam
doaj   +1 more source