Results 51 to 60 of about 10,832 (262)

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science
There is a pressing demand for neuroregenerative treatment for Alzheimer's disease (AD). Recently, a NeuroD1‐mediated neuroregeneration strategy has been proposed, yet its efficacy remains untested in non‐human primate (NHP) AD models closely reflecting ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
doaj   +1 more source

Cell unit-inspired natural nano-based biomaterials as versatile building blocks for bone/cartilage regeneration

Journal of Nanobiotechnology, 2023
The regeneration of weight-bearing bone defects and critical-sized cartilage defects remains a significant challenge. A wide range of nano-biomaterials are available for the treatment of bone/cartilage defects.
Fuxiao Wang, Zhengrong Gu, Zhifeng Yin, Wencai Zhang, Long Bai, Jiacan Su   +5 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Comparing natural regeneration of Norway spruce Picea abies (L.) Karst. in the Kaszuby Lake District and in the other regions of northern Poland

Leśne Prace Badawcze, 2017
The paper investigates the biometric characteristics natural Norway spruce (Picea abies (L.) Karst.) regeneration in the Kaszuby Lake District, which is beyond the acknowledged Norway spruce range, with the natural regeneration in the Augustów Forest ...
Szydlarski Marcin, Modrzyński Jerzy, Stopiński Mateusz, Majewski Michał, Maras Krzysztof   +4 more
doaj   +1 more source

Effects of gap size on natural regeneration and micro-environmental soil conditions in European beech (Fagus sylvatica L.) and Norway spruce (Picea abies (L.) Karst) dominated mixed forest

Plant, Soil and Environment, 2020
The study focused on the effects of gap size on natural regeneration of European beech (Fagus sylvatica L.) and Norway spruce (Picea abies L.) and micro-environmental soil conditions in gaps of different sizes under temperate mixed forest in the Czech ...
Maame Esi Hammond, Radek Pokorný
doaj   +1 more source

Economics of Naturally Regenerating, Heterogeneous Forests [PDF]

Journal of the Association of Environmental and Resource Economists, 2015
AbstractAn economic model for naturally regenerating, heterogeneous forests is specified to yield both clear-cuts and continuous cover forestry endogenously. The model includes nonconvexities and any number of state variables but is, in its simplest form, a one-state variable problem.
openaire   +2 more sources

Natural regeneration and management of birch [PDF]

, 2022
This thesis offers guidance for those who want to naturally establish, maintain and manage birch in monocultures and mixed stands. Silver and downy birch are the most common broadleaf tree species in northern Europe. In Sweden, the two species together make up approximately 12% of the standing forest volume.
openaire   +2 more sources

The Lupus Damage Index Revision Program: Results From the Item Generation and Reduction Phases

Arthritis Care &Research, EarlyView.
Objective A data‐driven and expert/patient consensus‐based project to develop a revised Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology (ACR) Damage Index (SDI) is under way supported by SLICC, ACR, and the Lupus Foundation of America. Our objective is to report the item generation and reduction phase results
Burak Kundakci, Megan R. W. Barber, Ann E. Clarke, Sindhu R. Johnson, Anselm Mak, Hermine I. Brunner, Murat Inanc, Rosalind Ramsey‐Goldman, Guillermo Ruiz‐Irastorza, Ellen M. Ginzler, John G. Hanly, Alexandra Legge, Cynthia Aranow, Laurent Arnaud, Nathalie Costedoat‐Chalumeau, Dafna D. Gladman, Søren Jacobsen, Michelle Petri, Clovis A. Silva, Évelyne Vinet, Alexandre E. Voskuyl, SDI Revision Literature Review Groups, SDI Revision Delphi Panel, SDI Revision Item Reduction Committee, SDI Revision Clinical Domain Groups, Ian N. Bruce   +25 more
wiley   +1 more source

Semantic Modeling in Materials Science and Engineering With Platform MaterialDigital Core Ontology 3.0

Advanced Engineering Materials, EarlyView.
The community‐driven Platform MaterialDigital Core Ontology (PMDco) 3.0 is introduced as a Basic Formal Ontology‐aligned semantic backbone for the processing–structure–properties paradigm in Materials Science and Engineering. Modular engineering, automated releases, and validation workflows are highlighted and key semantic patterns for materials ...
Markus Schilling, Philipp von Hartrott, Jörg Waitelonis, Thomas Hanke, Henk Birkholz, Hossein Beygi Nasrabadi, Khashayar Razghandi, Kamilla Zaripova, Felix Thonagel, Fabian Neuhaus, Martin Glauer, Lars Vogt, Harald Sack, Lutz Mädler, Bernd Bayerlein, Chris Eberl   +15 more
wiley   +1 more source

Soil carbon sequestration benefits of active versus natural restoration vary with initial carbon content and soil layer

Communications Earth & Environment, 2023
Active restoration of croplands more strongly enhances soil carbon relative to natural regeneration in carbon-poor soils and topsoil layers, while natural regeneration performs better in carbon-rich soils and subsoil layers, suggests a large-scale paired
Dashuan Tian, Yangzhou Xiang, Eric Seabloom, Jinsong Wang, Xiaoxu Jia, Tingting Li, Zhaolei Li, Jian Yang, Hongbo Guo, Shuli Niu   +9 more
doaj   +1 more source