Results 71 to 80 of about 5,737,694 (342)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Studies on mechanisms of augmentation of liver regeneration by cyclosporine and FK 506 [PDF]

, 1991
Evidence could not be found of immune modulation of liver regeneration. The powerful immunosuppressive drug FK 506, which augments the response after partial hepatectomy in normal rats, had the same effect in T cell—deficient nude rats.
Adrianni Zeevi, Antonio Francavilla, Fischer, Francavilla, Francavilla, Harding, Higgins, Itoh, Jirtle, Kahn, Kendrick A. Porter, Kim, Kino, Lowry, Makowka, Marcell R. M. van den Brink, Markus, Mazzaferro, Michalopoulos, Michele Barone, Peter M. Markus, Qi-Hua Zeng, Satoru Todo, Schreiber, Seglen, Siekierka, Starzl, Starzl, Thomas E. Starzl, Van der Brink   +29 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Olig2 acts as an inducible barrier to in vivo astrocyte-to-neuron conversion

Nature Communications
In vivo astrocyte-to-neuron (AtN) conversion suffers low efficiency due to pre-existing intrinsic barriers. However, it is unclear whether astrocytes have inducible barriers to reprogramming.
Chuying Lai, Kaiyu Hou, Wenyu Li, Jiahui Wang, Xiaoman Cai, Ya Shi, Miao Yang, Danting Yu, Kang Lu, Wen Li, Gong Chen, Zheng Wu   +11 more
doaj   +1 more source

Assessment of suitable habitat of the natural regeneration C. Libani A. Richard in Slenfeh (Syria)

Egyptian Journal of Remote Sensing and Space Sciences, 2021
This study evaluated the habitat suitability for the natural regeneration of C. libani A. Richard in the Cedar and Fire Reserve in Slenfeh region of ​​Syria.
Abeer Ibrahem, Emad Koubaily, Ali Thabeet   +2 more
doaj   +1 more source

Natural regeneration of broadleaved tree species in southern Sweden [PDF]

, 2001
The objective of the present thesis was to examine the effects of silvicultural treatments and seed dispersal from surrounding stands on the establishment of natural regeneration of broadleaved tree species in southern Sweden.
Karlsson, Matts
core  

Natural recovery of genetic diversity by gene flow in reforested areas of the endemic Canary Island pine, Pinus canariensis

, 2007
The endemic pine, Pinus canariensis, forms one of the main forest ecosystems in the Canary Islands. In this archipelago, pine forest is a mosaic of natural stands (remnants of past forest overexploitation) and artificial stands planted from the 1940's ...
Adams, Auckland, Brent C. Emerson, Chagné, DiFazio, Doyle, Dyer, El-Kassaby, Glaubitz, Glaubitz, Goldstein, González-Martínez, Gómez, Harju, Ledig, Ledig, Lefèvre, Lenormand, Lian, Miguel Navascués, Nathan, Nei, Nei, Nielsen, Parsons, Rannala, Raymond, Robledo-Arnuncio, Schuster, Soranzo, Vaxevanidou, Vendramin, Wang, Waples, Yazdani   +34 more
core   +4 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source