Results 61 to 70 of about 2,643,404 (347)
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Analysis of the Rights and Obligations of Stakeholders in China’s National Park Concession System
Fengjing YuanlinObjectiveThe establishment of a concession system is a pivotal endeavor for China’s transition into the era of national parks. The concession system is of paramount importance, as it has the potential to alleviate fiscal pressures on public funds ...
Le ZHONG, Zhicong ZHAO
doaj +1 more source
Molecular Oncology, EarlyView.Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source
Inter-organizational network relations of the 5th Development Document Plan with emphasize on natural resources [PDF]
مجله جنگل ایران, 2016 Planning, organizing, monitoring and controlling, leadership, evaluation and decision-making will not be possible and effective without communication.
دنیا خیرخواه +2 more
doaj
War and Natural Resource Exploitation [PDF]
Although the relationship between natural resources and civil war has received much attention, little is known about the underlying mechanisms. Controversies and contradictions in the stylized facts persist because resource extraction is treated as ...
Dominic Rohner, Frederick Van der Ploeg
core
Molecular Oncology, EarlyView.Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi +12 more
wiley +1 more source
Advances in AgricultureBarley is a significant cereal crop in Ethiopia, known for its rich genetic diversity, which includes both hulled and hull-less types adapted to the diverse agroecological zones of the country.
Asaye Demelash +2 more
doaj +1 more source
Indicators of Innovation in Canadian Natural Resource Industries [PDF]
This report develops a set of indicators of innovation in a number of the natural resource industries in Canada. It then uses these indicators to assess trends in innovation over time in these industries.
Andrew Sharpe, Olivier Guibaud
core
Molecular Oncology, EarlyView.Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh +5 more
wiley +1 more source