Results 21 to 30 of about 11,635,800 (364)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Fifth survey on weed flora in spring cereals in Finland

open access: yesAgricultural and Food Science, 2023
Regular weed surveys provide information on changes in weed communities. The composition of weed flora in spring cereal fields was investigated in southern and central Finland during 2020–2022.
Jukka Salonen   +6 more
doaj   +1 more source

Town of Hampton Stormwater Management PREP Natural Resources Outreach Coalition Grant Final Project Report [PDF]

open access: yes, 2010
PREP provided $3,500 towards the project which was matched by municipal funds to pay for consulting advice on improving the regulations. The Planning Board provided exceptional in-kind match on the project, with many hours of work spent by a volunteer ...
Natural Resources Outreach Coalition   +1 more
core   +2 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

Biodiversity in intensive and extensive grasslands in Finland: the impacts of spatial and temporal changes of agricultural land use

open access: yesAgricultural and Food Science, 2020
Biodiversity degradation is a national and global problem which is interconnected with land use and climate change. All these are major unsolved questions and their interactions are only partly understood.
Juha Tiainen   +10 more
doaj   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

A New Day, Full of Opportunity for Everyone [PDF]

open access: yes, 1990
https://digitalcommons.cwu.edu/government_posters/1025/thumbnail ...
United States Natural Resources Conservation Service
core   +1 more source

Minimal-time bioremediation of natural water resources [PDF]

open access: yes, 2011
We study minimal time strategies for the treatment of pollution of large volumes, such as lakes or natural reservoirs, with the help of an autonomous bioreactor. The control consists in feeding the bioreactor from the resource, the clean output returning
Cabrera, Hector Ramirez   +3 more
core   +6 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Swift recovery of Sphagnum carpet and carbon sequestration after shallow Sphagnum biomass harvesting [PDF]

open access: yesMires and Peat, 2017
White horticultural peat is a microbiologically active growing medium which binds significant quantities of nutrients and water due to its favourable cation exchange capacity and porosity.
N. Silvan   +3 more
doaj   +1 more source

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