Results 1 to 10 of about 1,778,444 (289)
ZEB2 and MEIS1 independently contribute to hematopoiesis via early hematopoietic enhancer activation
iScience, 2023 Summary: Cell differentiation is achieved by acquiring a cell type-specific transcriptional program and epigenetic landscape. While the cell type-specific patterning of enhancers has been shown to precede cell fate decisions, it remains unclear how ...
Yohko Kitagawa +4 more
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, 2021 I provide two arguments against value-free naturalism. Both are based on considerations concerning biological teleology. Value-free naturalism is the thesis that both (1) everything is, at least in principle, under the purview of the sciences and (2) all
A Wouters +34 more
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iScience, 2023 Summary: Animals achieve their first mating through the process of sexual maturation. This study examined the precise and detailed timing of a series of behavioral events, including wing expansion, first feeding, first excretion, and courtship, during ...
Ki-Hyeon Seong, Tadashi Uemura, Siu Kang
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Beyond speech: Exploring diversity in the human voice
iScience, 2023 Summary: Humans have evolved voluntary control over vocal production for speaking and singing, while preserving the phylogenetically older system of spontaneous nonverbal vocalizations such as laughs and screams.
Andrey Anikin +4 more
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iScience, 2023 Summary: Prostate cancer (PCa) is one of the most common malignant diseases of urinary system and has poor prognosis after progression to castration-resistant prostate cancer (CRPC), and increased cytosine methylation heterogeneity is associated with the
Qi Li +8 more
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iScience, 2023 Summary: Hepatocyte pyroptosis has been shown to be involved in liver damage progression. Previously, we found that growth arrest-specific 5 (GAS5) is a regulator of hepatic stellate cell (HSC) activation. However, whether GAS5 plays a role in hepatocyte
Zhichao Lang +10 more
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iScience, 2023 Summary: Clathrin-mediated endocytosis (CME) is an essential cellular process, conserved among eukaryotes. Yeast constitutes a powerful genetic model to dissect the complex endocytic machinery, yet there is a lack of specific pharmacological agents to ...
Davia Prischich +11 more
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Aurora B kinase erases monopolar microtubule-kinetochore arrays at the meiosis I-II transition
iScience, 2023 Summary: During meiosis, faithful chromosome segregation requires monopolar spindle microtubule-kinetochore arrays in MI to segregate homologous chromosomes, but bipolar in MII to segregate sister chromatids.
Sergio Villa-Consuegra +2 more
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Mitochondrial UQCC3 controls embryonic and tumor angiogenesis by regulating VEGF expression
iScience, 2023 Summary: Mitochondria play important roles in angiogenesis. However, the mechanisms remain elusive. In this study, we found that mitochondrial ubiquinol-cytochrome c reductase complex assembly factor 3 (UQCC3) is a key regulator of angiogenesis.
Guimin Zhang +18 more
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, 2018 We take the potentialities that are studied in the biological sciences (e.g., totipotency) to be an important subtype of biological dispositions. The goal of this paper is twofold: first, we want to provide a detailed understanding of what biological ...
A Bird +37 more
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