Results 131 to 140 of about 7,938,696 (303)
Occurrence of ‘Natural Selection’ in Successful Small Molecule Drug Discovery [PDF]
A highly curated dataset of published compounds from ChEMBL version 32 is used to seek evidence for the occurrence of ‘natural selection’ in drug discovery.
Lina, Heinzke +6 more
core +2 more sources
Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound
FEBS Open Bio, EarlyView.We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda +4 more
wiley +1 more source
Revista Chilena de Historia Natural, 2010 Evolutionary biology is experiencing an exceptional process of revisión and outreach because of the 200-anniversary if the birth of Charles Darwin. As a consequence, the study of organic evolution and also its teaching are being discussed at several ...
ROBERTO F NESPOLO
doaj
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
Memòria del Parc Natural dels Ports 2023 [PDF]
Gestió efectuada durant el 2023 al Parc Natural dels Ports, destacar les accions estratègiques i les fites més rellevants en cada un dels àmbits i línies de treball.[es] Gestión efectuada durante el 2023 en el Parque Natural de Els Ports, destaca las ...
Parc Natural dels Ports
core
Concepts of Drift and Selection in “The Great Snail Debate” of the 1950s and Early 1960s [PDF]
, 2007 Recently, much philosophical discussion has centered on the best way to characterize the concepts of random drift and natural selection, and, in particular, on the question of whether selection and drift can be conceptually distinguished (Beatty 1984 ...
Millstein, Roberta L.
core
Brain Evolution by Natural Selection
, 2006 Principles of Brain Evolution (Striedter 2005) places little emphasis on natural selection. However, one cannot fully appreciate the diversity of brains across species, nor the evolutionary processes driving such diversity, without an understanding of ...
Shimizu, Toru
core +1 more source
Disease-specific HIV Nef identified in multiple patients with neurological disorders and cancers
Journal of Virus Eradication, 2017 S. Lamers +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli +3 more
wiley +1 more source
Competition and its consequences for selection in barley breeding [PDF]
, 1979 The influence of competition is discussed and quantified for unselected bulk propagation, single-plant selection and yield testing of progenies in row plots.
Spitters, C.J.T.
core