Results 201 to 210 of about 1,205,213 (312)

A Sitewise Model of Natural Selection on Individual Antibodies via a Transformer-Encoder. [PDF]

Mol Biol Evol
Matsen FA, Sung K, Johnson MM, Dumm W, Rich D, Starr TN, Song YS, Bradley P, Fukuyama J, Haddox HK.   +9 more
europepmc   +1 more source

Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin, Tianyuan Yang, Minglei Liu, Haiyang Luo, Jing Yuan, Ke Zhang, Xinsheng Han, Jing Yang, Yuming Xu   +8 more
wiley   +1 more source

Darwinism: An Exposition of the Theory of Natural Selection With Some of Its Applications [PDF]

, 1975
Wallace, Alfred Russell
core   +1 more source

The Price Equation Reveals a Universal Force-Metric-Bias Law of Algorithmic Learning and Natural Selection. [PDF]

Entropy (Basel)
Frank SA.
europepmc   +1 more source

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias, Federica Avantaggiato, Gianni Pezzoli, Andrea Canessa   +3 more
wiley   +1 more source

Natural selection on reproductive timing varies by education in twentieth-century Estonia. [PDF]

Evol Hum Sci
Meitern R, Hõrak P.
europepmc   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Natural Selection of a Virus-Protective FUT2 Variant Following the Transition to Agriculture. [PDF]

Mol Biol Evol
Nordgren J, Ågren R, Hu DZ, Neijd M, Childebayeva A, Prüfer K, Hagbom M, Svensson L, Zeberg H.   +8 more
europepmc   +1 more source

Disease Course After Anti‐CD20 Discontinuation in Secondary Progressive Multiple Sclerosis—A Multicenter Long‐Term Longitudinal Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To describe long‐term outcomes after anti‐CD20 discontinuation in selected patients with secondary progressive multiple sclerosis (SPMS) who remained without subsequent disease‐modifying therapy (DMT). Methods We retrospectively analyzed data from four centers in Austria and Switzerland.
Ferdinand Otto, Dariia Kliushnikova, Richard Friedrich Radlberger, Sinan Yasaroglu, Tobias Moser, Andrea Harrer, Kitty Kratzer, Wolfgang Hitzl, Christiane Gradl, Martin Schmidauer, Patrick Roth, Harald Hegen, Peter Wipfler   +12 more
wiley   +1 more source

The <i>MUC19</i> gene: An evolutionary history of recurrent introgression and natural selection. [PDF]

Science
Villanea FA, Peede D, Kaufman EJ, Añorve-Garibay V, Chevy ET, Villa-Islas V, Witt KE, Zeloni R, Marnetto D, Moorjani P, Jay F, Valdmanis PN, Ávila-Arcos MC, Huerta-Sánchez E.   +13 more
europepmc   +1 more source