Results 41 to 50 of about 4,950,926 (242)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Spatial Analysis of a mixed Beech, Spruce and Fir stand in the Eastern Alps [PDF]

, 2010
In a forest reserve, located in the Eastern Italian Alps, a 4 ha permanent plot has been set up in a beech-spruce-fir multilayered forest, left to natural evolution for more than 30 years, in order to detect stand structure and spatial patterns ...
Marin, Alberto
core  

Population genetic diversity in Quercus robur and Ulmus laevis in Southern Urals (Russia): a comparatively study of adults and progeny in localities with contrast forest cover

Central European Forestry Journal, 2022
Extensive forest areas decreased and fragmented during anthropogenic development of the zone of broad-leaved forest tree species in Russia. The pedunculate oak (Quercus robur L.) and the European white elm (Ulmus laevis Pall.), important key components ...
Ianbaev Ruslan, Boronnikova Svetlana, Yanbaev Yulai, Gainanov Salavat, Kulagin Aleksey   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Structural diversity of selected oak stands (Quercus robur L.) on the Krotoszyn Plateau in Poland

Leśne Prace Badawcze, 2017
The oak forests growing on the Krotoszyn Plateau are the biggest and most valuable oak forest complexes in Poland. The purpose of this study was to analyze the structural diversity of oak (Q. robur L.) stands older than 140 years.
Szmyt Janusz
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Acorn production of pedunculate oak in northeast of Ukraine

Metsanduslikud Uurimused, 2023
We analysed the quantity and quality of Quercus robur L. acorns after years with a very poor yield under the canopy of natural oak stands of various compositions, ages and stock densities in the northeastern part of Ukraine.
Rumiantsev Maksym, Kobets Oleksii, Vysotska Natalia, Luk’yanets Volodymyr, Obolonyk Iryna, Tupchii Olha, Bondar Oleksandr, Nazarenko Vitalii   +7 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source