Results 121 to 130 of about 8,119,390 (363)
Molecular Oncology, EarlyView.Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu +11 more
wiley +1 more source
THE NATURE OF TRANSLATION TRANSFORMATIONS
, 2023 Though many linguists addressed and did research about transformation in translation, there is no consensus among scientists regarding the very concept of translation transformation. This article deals with the problems which translators face during their interpreting and translating.
openaire +2 more sources
On the nature of the Gardner transformation [PDF]
Journal of Mathematical Physics, 1981 It is shown that every higher Korteveg-de Vries equation can be included in a one-parameter family of integrable equations.
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Molecular Oncology, EarlyView.Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma +9 more
wiley +1 more source
Journal of Infection in Developing Countries, 2016 Introduction: Escherichia coli is a commensal bacterium in humans, animals, and the environment that is one of the microorganisms commonly resistant to antimicrobials. Cooked meat products, which are popular in China, are easily contaminated by E.
Tao Yu +7 more
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Frontiers in Cellular and Infection Microbiology, 2018 Haemophilus parasuis causes Glässer's disease and pneumonia, incurring serious economic losses in the porcine industry. In this study, natural competence was investigated in H. parasuis. We found competence genes in H.
Ke Dai +12 more
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Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
Exact solutions of the Laplace fractional boundary value problems via natural decomposition method
Open Physics, 2020 In this article, exact solutions of some Laplace-type fractional boundary value problems (FBVPs) are investigated via natural decomposition method. The fractional derivatives are described within Caputo operator.
Hajira +5 more
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bioRxiv, 2017 Acquisition of foreign DNA by natural transformation is an important mechanism of adaptation and evolution in diverse microbial species. Here, we characterize the mechanism of ComM, a broadly conserved AAA+ protein previously implicated in homologous ...
T. Nero +5 more
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A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
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