Results 101 to 110 of about 4,915,216 (233)

An Experimental Approach to Optimizing Automated Hybrid Ventilation in Complex Buildings [PDF]

open access: yes, 2012
Complex buildings such as hospitals and laboratories require intensive ventilation and cooling loads in order to meet operational demands. One way to reduce energy use while meeting these demanding requirements in complex buildings is the incorporation ...
Taylor, Nathan
core  

Developing Highly Effective Nanoparticle mRNA Therapeutic for Pediatric Acute Respiratory Distress Syndrome

open access: yesAdvanced Science, EarlyView.
Sepsis‑induced pediatric acute respiratory distress syndrome suppresses FOXF1 in lung endothelial cells which causes life‐threatening lung damage. To counter this, researchers developed nanoparticles that specifically target these cells and deliver FOXF1 mRNA.
Zicheng Deng   +14 more
wiley   +1 more source

Isocyanate‐Modified Melatplatin(IV) Enhances Antitumor Efficacy via TCF4/COL6A3‐Mediated Extracellular Matrix Remodeling and cGAS‐STING Pathway Activation in Bladder Cancer

open access: yesAdvanced Science, EarlyView.
A series of melatonin‐conjugated platinum(IV) prodrugs was functionalized with isocyanate chains (compounds 5‒12). MP‐12C (compound 11) was identified as the lead candidate, with optimal potency and safety. MP‐12C exhibited greater efficacy than cisplatin by increasing intracellular uptake, reshaping the extracellular matrix, activating the cGAS‐STING ...
Linhui Wang   +18 more
wiley   +1 more source

STING/Type I Interferon Pathway Activation Confers Multimodal Therapeutic Benefits in Osteomyelitis

open access: yesAdvanced Science, EarlyView.
STING/type I interferon signaling counteracts osteomyelitis through coordinated control of pain, bone destruction, and abscess formation. It inhibits pathogen‐induced nociceptor activation, restrains osteoclast‐mediated bone resorption, and suppresses IL‐1β‐driven neutrophil recruitment.
Yang Chen   +19 more
wiley   +1 more source

A comprehensive review of computational modeling, data analytics, and intelligent approaches to greenhouse ventilation systems

open access: yesSmart Agricultural Technology
Ventilation is the primary mechanism to control temperature, relative humidity, and carbon dioxide levels in greenhouses. Properly designed ventilation systems remove sensible and latent heat generated by solar radiation and crop transpiration while ...
Yoonhong Yi, Neslihan Akdeniz
doaj   +1 more source

Effects of Radiant Floor Heating Integrated with Natural Ventilation on Flow and Dispersion in a Newly Decorated Residence. [PDF]

open access: yesInt J Environ Res Public Health, 2022
Cui PY   +6 more
europepmc   +1 more source

Engineered Allosteric Biosensor for In Situ DNA Glycosylase Detection in Neuroblastoma Risk Stratification and Drug Resistance Monitoring

open access: yesAdvanced Science, EarlyView.
An engineered allosteric biosensor (UUU‐DZ‐tFNA) was developed, in which UDG specifically recognizes and activates a DNAzyme to achieve signal cycle amplification in a sequentially activatable mode. UUU‐DZ‐tFNA achieves in situ UDG detection across multiple biological levels and facilitates risk stratification and drug resistance monitoring of NB ...
Yaqing Lu   +10 more
wiley   +1 more source

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