Results 111 to 120 of about 114,377 (311)

Lactate‐Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo‐Immunotherapy by Suppressing Tumor PANoptosis

Advanced Science, EarlyView.
Tumor‐derived lactate establishes a metabolic lock that drives chemo‐immunotherapy resistance by suppressing PANoptosis. Mechanistically, KAT8 lactylates the mitochondrial translocator ANT2, which recruits PGAM5 to dephosphorylate CypD. This cascade restricts mitochondrial permeability transition pore opening, preventing pro‐inflammatory mtDNA leakage.
Sen Zhong, Wenlong Chen, Fanglong Liu, Shengyi Zhou, Bolin Yu, Yuying Wang, Xiqian Zhou, Xuehui Wang, Diya Liu, Zhuoyu Zhang, Xinran Wang, Mounia Lalouly, Yiwen Li, Zhefei Du, Tao Yan, Zhihui Xiao, Zhou Zhou, Huanhuan Zhu, Fengyuan Qian, Bowen Zheng, Lin Fang   +20 more
wiley   +1 more source

Assessment of natural ventilation strategy to decrease the risk of COVID 19 infection at a rural elementary school. [PDF]

Heliyon, 2023
Rey-Hernández JM, Arroyo-Gómez Y, San José-Alonso JF, Rey-Martínez FJ.   +3 more
europepmc   +1 more source

Bioinspired Passive Flow Routing to Mitigate Thrombosis in Prosthetic Heart Valves and Cardiovascular Devices

Advanced Science, EarlyView.
Bioinspired passive flow routing mitigates thrombosis in cardiovascular devices by redirecting a small fraction of forward flow into stagnation‐prone regions. Inspired by avian alula and aircraft slat mechanisms, strategically placed routing channels restore washout around mechanical heart valves, reducing low‐shear exposure by four orders of magnitude
Yevgeniy Kreinin, Mark Epshtein, Yahel Talmon, Tirosh Mekler, Itay Or, Mahli Raad, Gil Bolotin, Josué Sznitman, Netanel Korin   +8 more
wiley   +1 more source

Natural ventilation of a building with heating at multiple levels [PDF]

This paper describes the theoretical and experimental modelling of a room with low and high level openings and distributed heating at multiple levels.
Livermore, S. R., Woods, A. W.
core  

Numerical and experimental study of an airing device for controlled natural ventilation of a building [PDF]

, 2008
The rationale of an advanced natural ventilation system should be to control airflows and air temperature during winter, and to avoid unnecessary energy losses and local draught, while maintaining an adequate ventilation rate.
Simonetti M., Fracastoro G. V.
core   +1 more source

Natural Ventilation Strategies to Prevent Airborne Disease Transmission in Public Buildings

Eng
This paper evaluates the effectiveness of natural ventilation as a health and safety strategy in municipal buildings, focusing on its capacity to ensure indoor air quality and limit airborne disease transmission.
Jesús M. Ballesteros-Álvarez, Álvaro Romero-Barriuso, Ángel Rodríguez-Sáiz, Blasa María Villena-Escribano   +3 more
doaj   +1 more source

Effect of flow structures on natural ventilation performance in office model. [PDF]

J Vis (Tokyo), 2023
Yoon GY, Lee SJ, Kwon H, Kim JJ.
europepmc   +1 more source

Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice

Advanced Science, EarlyView.
Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai, Rhonda Kelley, Ying Lao, M. Immanuel Reyes Madlangsakay, Prasanta Paul, M. Alejandra Llanes‐Cuesta, Jun‐Feng Wang, René P. Zahedi, Jiming Kong, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

Natural ventilation by design [PDF]

, 1980
SIGLELD:f81/1068 / BLDSC - British Library Document Supply CentreGBUnited ...
Chartered Inst. of Building Services, London (UK)
core  

A frontal air intake may improve the natural ventilation in urban buses. [PDF]

Sci Rep, 2022
Alexei Pichardo-Orta F, Luna OAP, Cordero JRV.   +2 more
europepmc   +1 more source