Results 41 to 50 of about 3,493,599 (282)

The Efficacy and Safety of Bevacizumab/Irinotecan/Temozolomide (BIT) for Relapsed/Refractory Neuroblastoma: The UK Children's Cancer and Leukaemia Group Experience

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Patients with high‐risk neuroblastoma who either are refractory to induction chemotherapy or relapse following multi‐modal treatment have a dismal prognosis. Based on data from the BEACON trial, since 2021 the UK national guidelines recommend bevacizumab, irinotecan, and temozolomide (BIT) for patients with relapsed/refractory ...
Thomas J. Jackson, Menna Shamma, Upeka Senanayake, Shaimaa Sahmoud, Kathleen Duffin, Victoria Howard, David King, Ayesha Fathani, Blanche Lumb, Andrei Pobischan, Irum Latif Memon, Monzir Ahmed, Rhian Thomas, Gerard Millen, Yasmeen Alomari, Sucheta Vaidya, Lynley V. Marshall, Sally L. George, Ramya Ramanujachar, Juliet Gray, Paola Angelini   +20 more
wiley   +1 more source

Evolution of linear perturbations through a bouncing world model: Is the near Harrison-Zel'dovich spectrum possible via a bounce? [PDF]

, 2007
We present a detailed numerical study of the evolutions of cosmological linear perturbations through a simple bouncing world model based on two scalar fields.
Hwang, Jai-chan, Kim, Han Seek
core   +1 more source

Alveolar Soft Part Sarcoma in Pediatric and Young Adult Patients: A Report From the Children's Oncology Group Study ARST0332

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma occurring most commonly in adolescence and young adulthood. Methods We present the clinical characteristics, treatments, and outcomes of patients with newly diagnosed ASPS enrolled on the Children's Oncology Group study ARST0332.
Jacquelyn N. Crane, Wei Xue, Amira Qumseya, Thomas Scharschmidt, Kathryn R. Tringale, Oscar Lopez Nunez, Jiaqi Hu, Donald A. Barkauskas, Rajkumar Venkatramani, Sheri L. Spunt, Aaron R. Weiss, Noah C. Federman   +11 more
wiley   +1 more source

Rapid Response to Trametinib Combined With Chemotherapy for Infant BRAF‐Fused Chiasmatic Glioma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Infants, less than 1 year, with chiasmatic gliomas (ICG) present a major therapeutic challenge due to large tumor size, decreased vision, rapid progression, and poor response to vincristine/carboplatin chemotherapy. The majority have a BRAF fusion, which may respond to downstream MEK inhibitors but response time is slow. There are no safety or
Helen Toledano, Alexander Yelak, Walid Kaadan, Shlomo Caduri, Rivka Friedland, Orli Michaeli, Gad Dotan, Osnat Konen   +7 more
wiley   +1 more source

Global recognition of the importance of nature-based solutions to the impacts of climate change

Global Sustainability, 2020
Ecosystems across the globe are vulnerable to the effects of climate change, as are the communities that depend on them. However, ecosystems can also protect people from climate change impacts.
Nathalie Seddon, Elizabeth Daniels, Rowan Davis, Alexandre Chausson, Rian Harris, Xiaoting Hou-Jones, Saleemul Huq, Valerie Kapos, Georgina M. Mace, Ali Raza Rizvi, Hannah Reid, Dilys Roe, Beth Turner, Sylvia Wicander   +13 more
doaj   +1 more source

Blockchain-based Data Provenance for the Internet of Things

, 2019
As more and more applications and services depend on data collected and provided by Internet of Things (IoT) devices, it is of importance that such data can be trusted.
Bertino E., Eberhardt J., Polyzos G. C., Ramachandran A., Simmhan Y. L., Westerkamp M.   +5 more
core   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Aboveground and soil carbon in novel forest ecosystems in Singapore: A case study of abandoned plantation secondary forests

Plants, People, Planet
Societal Impact Statement Novel forest ecosystems consist of forest ecosystems dominated by non‐native tree species that are difficult to restore to their pre‐human disturbance states.
Zu Dienle Tan, Khairun Nisha Mohamed Ramdzan, Leah Mary Lilly Denoun, Muhammad Khairuldin Aziz, Ali Ibrahim, Harigampitage Manjari Jayathilake, Annabel Jia Yi Lim, Akash Verma, Zhen Hao Ng, Hui Ying Teo, Victor Hock Soon Khoo, Kwek Yan Chong, Yiwen Zeng   +12 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Nature‐Based Solutions for Europe's Sustainable Development [PDF]

Conservation Letters, 2015
Abstract Pursuing economic targets of job creation, growth, and innovation while tackling global environmental challenges, has long been seen as impossible. However, any long‐term economic competitiveness and security depends on the extent to which natural resources are used sustainably.
Joachim Maes, Sander Jacobs
openaire   +2 more sources