Results 61 to 70 of about 28,081,150 (260)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The Seeds We Sow

Journal of Awareness-Based Systems Change
Amid overlapping global crises, many individuals experience psychological distress, anxiety, hopelessness, and a diminished sense of agency. Scholars increasingly argue that this erosion of perceived significance may be as consequential as climate ...
Christine Wamsler
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Ecological significance of protected areas in the tropical mountains of Eastern Africa

Ecological Indicators
Protected areas (PAs) are a tool and strategy for achieving multiple forest management objectives. This study employed ecological indicators to evaluate the effectiveness of PAs in tropical mountains of Eastern Africa.
Marco Andrew Njana
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Combining machine learning and spatial data processing techniques for allocation of large-scale nature-based solutions

, 2023
The escalating impacts of climate change trigger the necessity to deal with hydro-meteorological hazards. Nature-based solutions (NBSs) seem to be a suitable response, integrating the hydrology, geomorphology, hydraulic, and ecological dynamics.
Abayneh Abebe, Yared, Vojinovic, Zoran, Sanchez Torres, Arlex, Mubeen, Adam, Djordjević, Slobodan, Caloir, Beatriz Emma Gutierrez, Ruangpan, Laddaporn, Plavsic, Jasna, Manojlovic, Natasa   +8 more
core   +1 more source

Quantifying the uncertainty of shoreline change predictions from a deep learning model

Applied Ocean Research
Predicting shoreline change is a vital aspect in sustainable coastal zone management. As numerous forms of uncertainty are inherent in the driving forces, morphological responses, and the modelling methodology used, it is much more realistic and useful ...
Tharindu Manamperi, Alma Rahat, Doug Pender, Demetra Cristaudo, Rob Lamb, Harshinie Karunarathna   +5 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Nature-Based Solutions and Climate Change – Four Shades of Green

, 2017
'Nature-based -solutions' (NbS) aim to use nature in tackling challenges such as climate change, food security, water resources, or disaster risk management.
Sveriges lantbruksuniversitet., Randrup, Thomas,, Konijnendijk, Cecil,   +2 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source