Results 51 to 60 of about 477,739 (260)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Natural dynamical connections [PDF]
Czechoslovak Mathematical Journal, 1991 Let \((Y,\pi,X)\) be a fibered manifold with \(\dim X=1\), \(\dim Y=1+m\), \((J^ r\pi,\;\pi_{r,s},\;J^ s\pi)\) and \((J^ r\pi,\;\pi_ r,\;X)\) the obvious jet bundles induced by \(\pi\). In a previous paper [Proc. Conf. Differ. Geom. Appl., Brno 1989, 276-287 (1990)] the author proved the existence and uniqueness of a connection of order \((r+1)\) on \(\
openaire +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Developing a novel instrument to assess human–nature relational values
People and NatureRelational values—the values embedded in relationships between people and nature—are increasingly recognized as critical for understanding sustainability transformations, particularly in relation to pro‐environmental behaviours and well‐being.
Kimberly M. Post
doaj +1 more source
Novel pathways to value nature: how guided forest bathing promotes new relationships with nature
Ecology and SocietyOur relationship with nature adapts to our daily nature routines and it is rarely challenged. Forest bathing has been studied for its well-being benefits, but its potential as a novel nature-based activity to enrich human-nature relationships has not yet
Matteo Giusti +3 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Noticing nature: The role of environmental awareness in promoting well‐being
People and NatureSpending time in natural environments is associated with enhanced well‐being, including reduced stress and improved cognitive restoration. This experimental study investigates whether these benefits can be amplified by providing environmental prompts to ...
Bethany Harries +4 more
doaj +1 more source