Results 121 to 130 of about 5,582,271 (307)
FEBS Open Bio, EarlyView.ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
Search for $C=+$ charmonium and XYZ states in $e^+e^-\to \gamma+ H$ at BESIII
, 2013 Within the framework of nonrelativistic quantum chromodynamics, we study the production of $C=+$ charmonium states $H$ in $e^+e^-\to \gamma~+~H$ at BESIII with $H=\eta_c(nS)$ (n=1, 2, 3, and 4), $\chi_{cJ}(nP)$ (n=1, 2, and 3), and $^1D_2(nD)$ (n=1 and 2)
Li, Yi-Jie +3 more
core +1 more source
Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells
FEBS Open Bio, EarlyView.UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca +6 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
ENVIRONMENTAL CONSTRAINTS, COMMODITY MIX, AND RESEARCH RESOURCE ALLOCATION [PDF]
The purpose of this paper is to show how the allocation of research resources among commodities and the effects of such allocations on the output mix depend upon (a) the initial production conditions, (b) the nature of the research production functions, (
Abel, Martin E., Welsch, Delane E.
core +1 more source
Statistics: A Cautionary Tale [PDF]
, 2020 Many of the numbers used to assess students are statistical in nature. The theoretical context underlying the production of a typical number or statistic used in student assessment is presented.
Zane, Len
core +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
Diversity, divergence time, and biogeography of the genus Albatrellus (Agaricomycetes, Russulales)
MycologyThe genus Albatrellus is an important group of stipitate terrestrial fungi in the order Russulales. Some species in the genus form ectomycorrhizae, mostly with trees of Pinaceae; some are well-known edible mushrooms.
Hong-Min Zhou +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source