Results 51 to 60 of about 819,835 (306)

Nature Recovery Now: How the new UK Government needs to act to address the biodiversity crisis with five key priorities. [PDF]

Biodiversity loss is a critical global concern with profound implications for ecosystems and human wellbeing. As one of the most nature-depleted countries in the world, the UK must act to secure a future for both people and nature.
Bennett, Ellen, Hawkins, Anna, Joe Glentworth, Catherine Hammond, Anna Hawkins, Glentworth, Joe, Ellen Bennett, Stephanie Webb, Hammond, Catherine, Webb, Stephanie   +9 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Differences in addiction and recovery gains according to gender : gender barriers and specific differences in overall strengths growth

, 2022
Background: There is growing evidence on the importance of a gendered understanding of recovery. Gender differences have been reported in relation to the nature and extent of substance use, pathways to and through substance use disorder and recovery ...
Patton, David, Best, David, Vanderplasschen , W, Abreu Minero, Valeria, Brown, Lorna, Abreu, V., Best, D., Patton, D., Vanderplasschen, Wouter, Brown, L.   +9 more
core   +1 more source

Criterion of single-phase fault nature of AC line considering the influence of commutation failure

电力工程技术, 2022
The amplitude of AC line current at the inverter side is affected by DC commutation failure and fluctuates for a short time after single-phase trip.The fluctuation range increases with the increase of the number of DC commutation failures,resulting in ...
LI Fengting, LIU Yushan, XIE Chao, LIU Jianxun, HUANG Fei   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Slower recovery in space before collapse of connected populations [PDF]

, 2013
Slower recovery from perturbations near a tipping point and its indirect signatures in fluctuation patterns have been suggested to foreshadow catastrophes in a wide variety of systems. Recent studies of populations in the field and in the laboratory have
Dai, Lei, Korolev, Kirill Sergeevich, Lei Dai, Gore, Jeff, Jeff Gore, Kirill S. Korolev   +5 more
core   +1 more source

A framework to identify and value ecosystem services and disservices with supply and demand

Environmental Challenges
Effective governance and management of ecosystem functions to promote human well-being and social equity require a clear understanding of supply and demand dynamics.
William Sidemo-Holm, Jeppe Aagard Kristensen   +1 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Recovery of the endangered Maui Parrotbill (Kiwikiu, Pseudonestor xanthophrys) [PDF]

, 2015
Species recovery programs are tasked with reversing the declines of threatened and endangered species and mitigating the threats to their populations.
Mounce, Hanna Lee, Maui Forest Bird Recovery Project   +1 more
core