Results 131 to 140 of about 421,693 (309)

Advancing Maternal Health with Long‐Acting Therapeutics: Priorities, Efficacy and Safety Considerations, and Emerging Technologies

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Maternal health remains a critical global concern, particularly in underserved populations and in low‐ and middle‐income countries where access to safe and effective therapeutics is limited. Despite the use of medications by most women during pregnancy, the exclusion of pregnant and lactating women from clinical trials has resulted in significant data ...
Rachel K. Scott   +7 more
wiley   +1 more source

Effects of Granisetron against Anticancer Chemotherapy-induced Nausea and Vomiting in Patients with Recurrent Advanced Breast Cancer

open access: bronze, 1995
Tsunehito Kimura   +9 more
openalex   +2 more sources

More Than a Question of Correlation: Characterization of the Evidentiary Basis for Biomarker Surrogates Used in European Marketing Authorizations

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Traditionally, clinical outcomes measuring how a patient feels, functions, or survives are preferred endpoints in clinical trials; however, some may take a long time to manifest in slowly developing diseases. Biomarkers, if properly validated, can serve as surrogate endpoints, acting as substitutes for clinical outcomes.
Renske Johanna Grupstra   +4 more
wiley   +1 more source

Novel antiemetic effect of naldemedine in patients initiating opioids for cancer pain: a secondary analysis of a randomized clinical trial. [PDF]

open access: yesOncologist
Higashibata T   +23 more
europepmc   +1 more source

Cytologic Findings in Esophageal Perforation: An Institutional Experience With Pleural Fluid Specimens

open access: yesDiagnostic Cytopathology, EarlyView.
ABSTRACT Introduction Esophageal perforation (EP) is a rare but life‐threatening condition, and most cases are due to iatrogenic causes. The rest occur spontaneously, due to malignancies, or trauma. The mortality rates can approach 50%, and delayed diagnosis of EP exacerbates patient outcomes.
Mason Marshall   +3 more
wiley   +1 more source

Understanding Engagement Experiences in an Adapted Digital Cognitive Behavioral Intervention for Lower‐Income Adults With Eating Disorders With Binge Eating and/or Purging: A Qualitative Analysis of Barriers and Facilitators

open access: yesInternational Journal of Eating Disorders, EarlyView.
ABSTRACT Objective This study explored the experiences of lower‐income adults in accessing and engaging with an adapted digital guided self‐help cognitive behavioral intervention for binge and/or purge‐type eating disorders. This study sought to inform future adaptation of evidence‐based eating disorder interventions to improve accessibility ...
Kimberly Yu   +6 more
wiley   +1 more source

Interventional therapies for chronic heart failure: An overview of recent developments

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 1081-1094, April 2025.
Abstract Heart failure (HF), the final manifestation of most cardiovascular diseases, has become a major global health concern, affecting millions of individuals. Despite basic drug treatments, patients present with high morbidity and mortality rates. However, recent advancements in interventional therapy have shown promising results in improving the ...
Bingchen Guo   +7 more
wiley   +1 more source

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