Results 1 to 10 of about 9,275 (242)

An approach to targeting Nav1.7 for pain sensations [PDF]

The Journal of Clinical Investigation
Pain is a serious medical condition with current treatments remaining limited by side effects. The Nav1.7 voltage-gated sodium channel is a crucial determinant of nociceptor excitability and a promising target for nonaddictive analgesics.
Theodore R. Cummins
doaj   +4 more sources

Histone lactylation regulates DOCK4 to control heat nociception and supports Dynein-mediated Nav1.7 trafficking [PDF]

Nature Communications
Heat nociception involves thermosensors like transient receptor potential channel V1 in dorsal root ganglion (DRG) neurons, but their loss only partially impairs heat sensing, suggesting other mechanisms.
Man-Xiu Xie, Ren-Chun Lai, Yi-Bin Xiao, Shi-Yu Zuo, Hao Tang, Xian-Ying Cao, Jin-Kun Liu, Zi-Su Zhou, Shu-Hang Wang, Xiao-Fan Lu, Ying He, Yan Xie, Xiao-Long Zhang   +12 more
doaj   +3 more sources

Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain [PDF]

Toxins, 2016
Loss-of-function mutations of NaV1.7 lead to congenital insensitivity to pain, a rare condition resulting in individuals who are otherwise normal except for the inability to sense pain, making pharmacological inhibition of NaV1.7 a promising therapeutic ...
Jennifer R. Deuis, Joshua S. Wingerd, Zoltan Winter, Thomas Durek, Zoltan Dekan, Silmara R. Sousa, Katharina Zimmermann, Tali Hoffmann, Christian Weidner, Mohammed A. Nassar, Paul F. Alewood, Richard J. Lewis, Irina Vetter   +12 more
doaj   +4 more sources

Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release. [PDF]

PLoS ONE, 2016
Human genetic studies show that the voltage gated sodium channel 1.7 (Nav1.7) is a key molecular determinant of pain sensation. However, defining the Nav1.7 contribution to nociceptive signalling has been hampered by a lack of selective inhibitors.
Aristos J Alexandrou, Adam R Brown, Mark L Chapman, Mark Estacion, Jamie Turner, Malgorzata A Mis, Anna Wilbrey, Elizabeth C Payne, Alex Gutteridge, Peter J Cox, Rachel Doyle, David Printzenhoff, Zhixin Lin, Brian E Marron, Christopher West, Nigel A Swain, R Ian Storer, Paul A Stupple, Neil A Castle, James A Hounshell, Mirko Rivara, Andrew Randall, Sulayman D Dib-Hajj, Douglas Krafte, Stephen G Waxman, Manoj K Patel, Richard P Butt, Edward B Stevens   +27 more
doaj   +2 more sources

A Review of the Therapeutic Targeting of SCN9A and Nav1.7 for Pain Relief in Current Human Clinical Trials

Journal of Pain Research, 2023
Anton Dormer,1 Mahesh Narayanan,1 Jerome Schentag,1 Daniel Achinko,1 Elton Norman,1 James Kerrigan,2 Gary Jay,2 William Heydorn2 1Research and Development, Pepvax, Inc, Silver Spring, MD, USA; 2Research and Development, Navintus, Inc, Princeton, NJ ...
Dormer A, Narayanan M, Schentag J, Achinko D, Norman E, Kerrigan J, Jay G, Heydorn W   +7 more
doaj   +2 more sources

Ectopic expression of Nav1.7 in spinal dorsal horn neurons induced by NGF contributes to neuropathic pain in a mouse spinal cord injury model

Frontiers in Molecular Neuroscience, 2023
Neuropathic pain (NP) induced by spinal cord injury (SCI) often causes long-term disturbance for patients, but the mechanisms behind remains unclear. Here, our study showed SCI-induced ectopic expression of Nav1.7 in abundant neurons located in deep and ...
Yan Fu, Yan Fu, Liting Sun, Fengting Zhu, Fengting Zhu, Wei Xia, Ting Wen, Ruilong Xia, Xin Yu, Dan Xu, Changgeng Peng   +10 more
doaj   +2 more sources

Preclinical Animal Models to Investigate the Role of Na_v1.7 Ion Channels in Pain. [PDF]

Life (Basel)
Chronic pain is a maladaptive neurological disease that remains a major global healthcare problem. Voltage-gated sodium channels (Navs) are major drivers of the excitability of sensory neurons, and the Nav subtype 1.7 (Nav1.7) has been shown to be ...
Yogi A, Banderali U, Moreno MJ, Martina M.   +3 more
europepmc   +2 more sources

The Plant Alkaloid Harmaline Blocks the Voltage-Gated Sodium Channel Na_v1.7: A Study Using an Automated Patch-Clamp. [PDF]

Int J Mol Sci
The voltage-gated sodium channel Nav1.7 is essential for pain perception and is an interesting target for the development of pain-relieving substances.
Eisfeld J, Schumacher M, Krautwald M, Wierschke S, Qin L, Fechtali T, Brinkmeier H.   +6 more
europepmc   +2 more sources

Compartment-specific regulation of NaV1.7 in sensory neurons after acute exposure to TNF-α

Cell Reports
Summary: Tumor necrosis factor α (TNF-α) is a major pro-inflammatory cytokine, important in many diseases, that sensitizes nociceptors through its action on a variety of ion channels, including voltage-gated sodium (NaV) channels. We show here that TNF-α
Sidharth Tyagi, Grant P. Higerd-Rusli, Mohammad-Reza Ghovanloo, Fadia Dib-Hajj, Peng Zhao, Shujun Liu, Dong-Hyun Kim, Ji Seon Shim, Kang-Sik Park, Stephen G. Waxman, Jin-Sung Choi, Sulayman D. Dib-Hajj   +11 more
doaj   +2 more sources

Therapeutic targeting of voltage-gated sodium channel NaV1.7 for cancer metastasis

Frontiers in Pharmacology
This review focuses on the expression and function of voltage-gated sodium channel subtype NaV1.7 in various cancers and explores its impact on the metastasis driving cell functions such as proliferation, migration, and invasiveness.
Piyasuda Pukkanasut, Renata Jaskula-Sztul, Renata Jaskula-Sztul, Juan Carlos Gomora, Sadanandan E. Velu, Sadanandan E. Velu   +5 more
doaj   +2 more sources