Nuclear Factor-kappaB Gates Nav1.7 Channels in DRG Neurons via Protein-Protein Interaction
iScience, 2019 Summary: It is well known that nuclear factor-kappaB (NF-κB) regulates neuronal structures and functions by nuclear transcription. Here, we showed that phospho-p65 (p-p65), an active form of NF-κB subunit, reversibly interacted with Nav1.7 channels in ...
Man-Xiu Xie +8 more
doaj +1 more source
Frontiers in Neuroscience, 2021 Charcot neuroarthropathy is a systemic disease with pathological changes in the musculoskeletal system, which leads to fractures, dislocations, and deformities involving multiple bones and joints, particularly those of the feet.
Xiao-hui Xie +7 more
doaj +1 more source
Evaluation of behavior in transgenic mouse models to understand human congenital pain conditions [PDF]
, 2018 BACKGROUND: Containing a brain for signal processing and decision making, and a peripheral component for sensation and response, the nervous system provides higher organisms a powerful method of interacting with their environment.
Bullock, Daniel
core
Voltage-gated sodium channels potentiate the invasive capacities of human non-small-cell lung cancer cell lines. [PDF]
, 2007 Ionic channel activity is involved in fundamental cellular behaviour and participates in cancerous features such as proliferation, migration and invasion which in turn contribute to the metastatic process.
Barascu, Aurélia +9 more
core +3 more sources
Loss-of-function mutations in sodium channel Nav1.7 cause anosmia [PDF]
Nature, 2011 Loss of function of the gene SCN9A, encoding the voltage-gated sodium channel Na(v)1.7, causes a congenital inability to experience pain in humans. Here we show that Na(v)1.7 is not only necessary for pain sensation but is also an essential requirement for odour perception in both mice and humans.
Jan, Weiss +12 more
openaire +2 more sources
The role of disulfide bond replacements in analogues of the Tarantula toxin ProTx-II and their effects on inhibition of the voltage-gated sodium ion channel Nav1.7 [PDF]
, 2017 Spider venom toxins, such as Protoxin-II (ProTx-II), have recently received much attention as selective Nav1.7 channel blockers, with potential to be developed as leads for the treatment of chronic nocioceptive pain.
Cryar, Adam +12 more
core +2 more sources
Depletion of membrane cholesterol modifies structure, dynamic and activation of Nav1.7
bioRxivCholesterol is a major component of plasma membranes and unsurprisingly plays a significant role in actively regulating the functioning of several membrane proteins in humans.
Simone Albani +5 more
semanticscholar +1 more source
Elucidating molecular mechanisms of protoxin-II state-specific binding to the human NaV1.7 channel
The Journal of General Physiology, 2023 NaV1.7, a voltage-gated sodium channel, plays a crucial role in pain perception and is specifically targeted by PTx2, which serves as a template for designing pain therapeutics. In this study, Ngo et al.
K. Ngo +8 more
semanticscholar +1 more source
Burn Selection: How Fire Injury Shaped Human Evolution
BioEssays, Volume 48, Issue 2, February 2026.Intentional fire use exposed humans and their ancestors to high‐temperature burn injury, a risk rare in other species, bringing major survival benefits and technologies but also repeated exposure to extreme heat. The Burn Selection Hypothesis reframes this cost of fire mastery as a unique selective pressure, which shaped our evolution.
Joshua Cuddihy +9 more
wiley +1 more source
Genetics update: monogenetics, polygene disorders and the quest for modifying genes [PDF]
, 2018 The genetic channelopathies are a broad collection of diseases. Many ion channel genes demonstrate wide phenotypic pleiotropy, but nonetheless concerted efforts have been made to characterise genotype-phenotype relationships.
Symonds, Joseph D., Zuberi, Sameer M.
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